Evidence map›Paper›PMID 39605567›Full record

ArticlebioRxiv : the preprint server for biology2024

Cancer-associated SF3B1 mutation K700E causes widespread changes in U2/branchpoint recognition without altering splicing.

Andrey Damianov, Chia-Ho Lin, Jian Zhang, James L Manley, Douglas L Black

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Andrey DamianovDepartment of Microbiology, Immunology, and Molecular Genetics, Molecular Biology Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA.ORCID 0009-0001-9845-913X
Chia-Ho LinDepartment of Microbiology, Immunology, and Molecular Genetics, Molecular Biology Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA.ORCID 0000-0002-2690-9648
Jian ZhangDepartment of Biological Sciences, Columbia University, New York, NY.ORCID 0000-0001-7565-1471
James L ManleyDepartment of Biological Sciences, Columbia University, New York, NY.ORCID 0000-0002-8341-1459
Douglas L BlackDepartment of Microbiology, Immunology, and Molecular Genetics, Molecular Biology Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA.ORCID 0000-0002-2705-8187

Funding

Regulation of RNA processing: Mechanisms and ConsequencesR35GM118136 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI James L. Manley · 2016 to 2026
$8.9M
Mechanisms of Post-transcriptional Gene Regulation by RNA Binding ProteinsR35GM136426 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Douglas L Black · 2020 to 2026
$5.4M
Identification of novel splicing regulatory complexesR01GM127473 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DAMIANOV, ANDREY · 2019 to 2023
$1.6M
Comprehensive Maps of U1 snRNP Binding to Nascent RNA in Human CellsR21HG012624 · NHGRI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BLACK, DOUGLAS L · 2022 to 2022
$429k
NHGRI NIH HHS R21 HG012624NIGMS NIH HHS R01 GM127473NIGMS NIH HHS R35 GM118136NIGMS NIH HHS R35 GM136426
6 · The paper itself

Abstract

Myelodysplastic syndromes and other cancers are often associated with mutations in the U2 snRNP protein SF3B1. Common SF3B1 mutations, including K700E, disrupt SF3B1 interaction with the protein SUGP1 and induce aberrant activation of cryptic 3' splice sites (ss), presumably resulting from aberrant U2/branch site (BS) recognition by the mutant spliceosome. Here, we apply the new method of U2 IP-seq to profile BS binding across the transcriptome of K562 leukemia cells carrying the

Identifiers

PMID39605567
PMCPMC11601671

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.