Evidence map›Paper›PMID 39605563›Full record

ArticlebioRxiv : the preprint server for biology2024

Targeting GOF p53 and c-MYC through LZK Inhibition or Degradation Suppresses Head and Neck Tumor Growth.

Amy L Funk, Meghri Katerji, Marwa Afifi, Katherine Nyswaner, Carolyn C Woodroofe, Zoe C Edwards, Eric Lindberg, Knickole L Bergman, Nancy R Gough, Maxine R Rubin and 17 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Amy L FunkLaboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute at Frederick, NIH, Frederick, MD 21702, USA.
Meghri KaterjiLaboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute at Frederick, NIH, Frederick, MD 21702, USA.
Marwa AfifiLaboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-4255, USA.
Katherine NyswanerLaboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute at Frederick, NIH, Frederick, MD 21702, USA.
Carolyn C WoodroofeChemistry and Synthesis Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Rockville, MD 20850, USA.
Zoe C EdwardsCell Division Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK.
Eric LindbergChemistry and Synthesis Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Rockville, MD 20850, USA.
Knickole L BergmanLaboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute at Frederick, NIH, Frederick, MD 21702, USA.
Nancy R GoughBioSerendipity, LLC, Frederick, MD 21702, USA.
Maxine R RubinLaboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute at Frederick, NIH, Frederick, MD 21702, USA.
Kamila KarpińskaLaboratory of Molecular OncoSignalling, IMol Polish Academy of Sciences, Warsaw, Poland.
Eleanor W TrotterCell Division Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK.
Sweta DashLaboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute at Frederick, NIH, Frederick, MD 21702, USA.
Amy L RiesLaboratory Animal Sciences Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Amy JamesLaboratory Animal Sciences Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Christina M RobinsonLaboratory Animal Sciences Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Simone DifilippantonioLaboratory Animal Sciences Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Baktiar O KarimMolecular Histopathology Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Ting-Chia ChangMolecular Characterization Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Li ChenMolecular Characterization Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Xin XuDivision of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, Rockville, MD 20850, USA.
James H DoroshowDivision of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, Rockville, MD 20850, USA.
Ivan AhelSir William Dunn School of Pathology, Oxford UK, OX1 3RE.
Anna A MarusiakLaboratory of Molecular OncoSignalling, IMol Polish Academy of Sciences, Warsaw, Poland.
Rolf E SwensonChemistry and Synthesis Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Rockville, MD 20850, USA.
Steven D CappellLaboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-4255, USA.
John BrognardLaboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute at Frederick, NIH, Frederick, MD 21702, USA.

Funding

Training in Environment ToxicologyT32ES007026 · NIEHS · UNIVERSITY OF ROCHESTER · PI Alison Elder, Marissa Sobolewski Terry · 1985 to 2026
$20.2M
Oncogenic Kinases in CancerZIABC011691 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BROGNARD, JOHN · 2016 to 2025
$14.4M
Intramural NIH HHS ZIA BC011691NCI NIH HHS HHSN261201500003CNCI NIH HHS HHSN261201500003INIEHS NIH HHS T32 ES007026
6 · The paper itself

Abstract

The worldwide frequency of head and neck squamous cell carcinoma (HNSCC) is approximately 800,000 new cases, with 430,000 deaths annually. We determined that LZK (encoded by

Identifiers

PMID39605563
PMCPMC11601640

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.