Evidence map›Paper›PMID 39605550›Full record

ArticlebioRxiv : the preprint server for biology2024

Dietary Restriction Enhances CD8

Brandon M Oswald, Lisa M DeCamp, Joseph Longo, Michael S Dahabieh, Nicholas Bunda, Shixin Ma, McLane J Watson, Ryan D Sheldon, Michael P Vincent, Benjamin K Johnson and 10 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Brandon M OswaldDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Lisa M DeCampDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Joseph LongoDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Michael S DahabiehDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Nicholas BundaDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Shixin MaSalk Institute.
McLane J WatsonDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Ryan D SheldonMass Spectrometry Core Facility, Van Andel Institute, Grand Rapids, MI, USA.
Michael P VincentMetabolism and Nutrition (MeNu) Program, Van Andel Institute, Grand Rapids, MI, USA.
Benjamin K JohnsonDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.
Abigail E EllisMass Spectrometry Core Facility, Van Andel Institute, Grand Rapids, MI, USA.
Molly T Soper-HopperMass Spectrometry Core Facility, Van Andel Institute, Grand Rapids, MI, USA.
Christine N IsaguirreMass Spectrometry Core Facility, Van Andel Institute, Grand Rapids, MI, USA.
Hui ShenDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.
Kelsey S WilliamsDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Peter A CrawfordDepartment of Medicine, Division of Molecular Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
Susan KaechSalk Institute.
H Josh JangDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.ORCID 0000-0001-9654-4448
Connie M KrawczykDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.ORCID 0000-0002-2468-5986
Russell G JonesDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.ORCID 0000-0003-2250-4675

Funding

Regulation of memory CD8 T cell developmentR01AI066232 · NIAID · YALE UNIVERSITY · PI Diana Clare Hargreaves · 2005 to 2026
$5.7M
Ketone Body Metabolism in CD8+ T Cell ResponsesR01AI165722 · NIAID · VAN ANDEL RESEARCH INSTITUTE · PI JONES, RUSSELL GRAHAM · 2022 to 2025
$3.3M
Cancer Epigenetics Training (CET) ProgramT32CA251066 · NCI · VAN ANDEL RESEARCH INSTITUTE · PI Scott Rothbart · 2021 to 2026
$2.4M
Dietary regulation of anti-tumor immunity through caloric restrictionU01CA297713 · NCI · VAN ANDEL RESEARCH INSTITUTE · PI Russell Graham Jones · 2025 to 2026
$1.5M
Metabolic regulation of epigenetic states in CD8 T cell exhaustionR21AI151986 · NIAID · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI KAECH, SUSAN M · 2020 to 2021
$529k
Chromatin architecture as a determinant of dendritic cell functionR21AI153997 · NIAID · VAN ANDEL RESEARCH INSTITUTE · PI KRAWCZYK, CONNIE · 2020 to 2021
$523k
NCI NIH HHS T32 CA251066NCI NIH HHS U01 CA297713NIAID NIH HHS R01 AI066232NIAID NIH HHS R01 AI165722NIAID NIH HHS R21 AI151986NIAID NIH HHS R21 AI153997
6 · The paper itself

Abstract

Reducing calorie intake without malnutrition limits tumor progression but the underlying mechanisms are poorly understood. Here we show that dietary restriction (DR) suppresses tumor growth by enhancing CD8

Identifiers

PMID39605550
PMCPMC11601469

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.