ArticlebioRxiv : the preprint server for biology2024
Single nucleus RNA-sequencing reveals transcriptional synchrony across different relationships.
Liza E Brusman, Julie M Sadino, Allison C Fultz, Michael A Kelberman, Robin D Dowell, Mary A Allen, Zoe R Donaldson
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
7 authors.
Liza E BrusmanDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder; Boulder, CO 80309 USA.
Julie M SadinoDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder; Boulder, CO 80309 USA.
Allison C FultzDepartment of Psychology and Neuroscience, University of Colorado Boulder; Boulder, CO, 80309 USA.
Michael A KelbermanDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder; Boulder, CO 80309 USA.
Robin D DowellDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder; Boulder, CO 80309 USA.
Mary A AllenDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder; Boulder, CO 80309 USA.
Zoe R DonaldsonDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder; Boulder, CO 80309 USA.ORCID 0000-0001-6699-7905 Funding
TRAINING IN SIGNAL TRANSDUCTION &CELL CYCLE REGULATIONT32GM008759 · NIGMS · UNIVERSITY OF COLORADO AT BOULDER · PI AHN, NATALIE G. · 2000 to 2020
$5.9MHippocampal neural dynamics driving affiliation and attachmentUF1NS122124 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DONALDSON, ZOE REBECCA, GOLSHANI, PEYMAN · 2021 to 2021
$4.8MDynamic entanglements: the functional role and mechanistic basis of inter-individual neural synchronyU01NS131406 · NINDS · NORTHWESTERN UNIVERSITY · PI DONALDSON, ZOE REBECCA, KOZOROVITSKIY, YEVGENIA · 2023 to 2025
$4.2MPredoctoral Training Program in Signaling and Cellular Regulation INCLUDE Down Syndrome SupplementT32GM142607 · NIGMS · UNIVERSITY OF COLORADO · PI Sabrina Leigh Spencer, Tin Tin Su · 2021 to 2026
$3.6MThe neuromolecular basis of adaptation to bond lossR01MH125423 · NIMH · UNIVERSITY OF COLORADO · PI Zoe Rebecca Donaldson · 2022 to 2026
$2.6MNeuronal basis of social motivation and the failure to adapt to lossDP2MH119427 · NIMH · UNIVERSITY OF COLORADO · PI DONALDSON, ZOE REBECCA · 2018 to 2019
$2.5MFunction of RUNX1 in diverse Down syndrome tissuesR01HL156475 · NHLBI · UNIVERSITY OF COLORADO · PI ALLEN, MARY A · 2021 to 2023
$2.1MThe Role of Neuronal Ensembles Supporting Auditory Fear Conditioning (Engrams) in the Amygdala in Memory Formation, Generalization and ExtinctionR01MH119421 · NIMH · HOSPITAL FOR SICK CHLDRN (TORONTO) · PI FRANKLAND, PAUL, JOSSELYN, SHEENA A · 2019 to 2023
$1.7MEmergent behavioral and transcriptional properties of pair bondsF31MH132278 · NIMH · UNIVERSITY OF COLORADO · PI BRUSMAN, LIZA EDEN · 2023 to 2024
$61kNHLBI NIH HHS R01 HL156475NIGMS NIH HHS T32 GM008759NIGMS NIH HHS T32 GM142607NIMH NIH HHS DP2 MH119427NIMH NIH HHS F31 MH132278NIMH NIH HHS R01 MH119421NIMH NIH HHS R01 MH125423NINDS NIH HHS U01 NS131406NINDS NIH HHS UF1 NS122124
6 · The paper itselfAbstract
As relationships mature, partners share common goals, improve their ability to work together, and experience coordinated emotions. However, the neural underpinnings responsible for this unique, pair-specific experience remain largely unexplored. Here, we used single nucleus RNA-sequencing to examine the transcriptional landscape of the nucleus accumbens (NAc) in socially monogamous prairie voles in peer or mating-based relationships. We show that, regardless of pairing type, prairie voles exhibit transcriptional synchrony with a partner. Further, we identify genes expressed in oligodendrocyte progenitor cells that are synchronized between partners, correlated with dyadic behavior, and sensitive to partner separation. Together, our data indicate that the pair-specific social environment profoundly shapes transcription in the NAc. This provides a potential biological mechanism by which shared social experience reinforces and strengthens relationships.
Identifiers
PMID39605537
PMCPMC11601461
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