Evidence map›Paper›PMID 39605502›Full record

ArticlebioRxiv : the preprint server for biology2024

International multi-cohort analysis identifies novel framework for quantifying immune dysregulation in critical illness: results of the SUBSPACE consortium.

Andrew R Moore, Hong Zheng, Ananthakrishnan Ganesan, Yehudit Hasin-Brumshtein, Manoj V Maddali, Joseph E Levitt, Tom van der Poll, Brendon P Scicluna, Evangelos J Giamarellos-Bourboulis, Antigone Kotsaki and 15 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors.

Andrew R MooreDivision of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, CA.ORCID 0000-0001-8040-2576
Hong ZhengInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA.
Ananthakrishnan GanesanInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA.
Yehudit Hasin-BrumshteinInflammatix, Inc. Sunnyvale, CA.
Manoj V MaddaliDivision of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, CA.
Joseph E LevittDivision of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, CA.
Tom van der PollCenter of Experimental and Molecular Medicine, Amsterdam University Medical Centers, University of Amsterdam, the Netherlands.
Brendon P SciclunaDepartment of Applied Biomedical Science, University of Malta, Malta.
Evangelos J Giamarellos-Bourboulis4 Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Greece.
Antigone Kotsaki4 Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Greece.
Ignacio Martin-LoechesDepartment of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO), St James's Hospital, Dublin, Ireland.
Alexis GardunoDepartment of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO), St James's Hospital, Dublin, Ireland.
Richard E RothmanDepartment of Emergency Medicine, The Johns Hopkins University, Baltimore, MD.
Jonathan SevranskyDepartment of Emergency Medicine, Emory University, Atlanta, GA.
David W WrightDepartment of Emergency Medicine, Emory University, Atlanta, GA.
Mihir R AtreyaDivision of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, College of Medicine, OH.
Lyle L MoldawerSepsis and Critical Illness Research Center and the SPIES Consortium, University of Florida College of Medicine, Gainesville, FL.
Philip A EfronSepsis and Critical Illness Research Center and the SPIES Consortium, University of Florida College of Medicine, Gainesville, FL.
Kralovcova Marcela1 Department of Internal Medicine, Faculty of Medicine, Teaching Hospital and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic.
Thomas Karvunidis1 Department of Internal Medicine, Faculty of Medicine, Teaching Hospital and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic.
Heather M GianniniDivision of Pulmonary, Allergy, and Critical Care Medicine, Perelman School of Medicine University of Pennsylvania, Philadelphia PA.
Nuala J MeyerDivision of Pulmonary, Allergy, and Critical Care Medicine, Perelman School of Medicine University of Pennsylvania, Philadelphia PA.
Timothy E SweeneyInflammatix, Inc. Sunnyvale, CA.
Angela J RogersDivision of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, CA.
Purvesh KhatriInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA.ORCID 0000-0002-4143-4708

Funding

Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5M
Systems biological assessment of T cell responses to vaccinationU19AI167903 · NIAID · STANFORD UNIVERSITY · PI BALI PULENDRAN · 2022 to 2026
$13.2M
Investigating Individual Susceptibility and Host Response in Acute Respiratory Distress SyndromeR35HL161196 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Nuala Jennings Meyer · 2022 to 2026
$4.8M
Stanford Training Program in Lung BiologyT32HL129970 · NHLBI · STANFORD UNIVERSITY · PI CORNFIELD, DAVID N., NICOLLS, MARK ROBERT · 2016 to 2025
$3.2M
Molecular characterization of pulmonary edema: a window to an injured lungR01HL152083 · NHLBI · STANFORD UNIVERSITY · PI ROGERS, ANGELA J · 2020 to 2024
$2.9M
Translational approaches to unravel organ-specific microvascular endothelial responses in sepsis.R35GM155165 · NIGMS · CINCINNATI CHILDRENS HOSP MED CTR · PI Mihir R Atreya · 2024 to 2026
$1.2M
Leveraging multi-omics to maximize the scientific value of pediatric sepsis biorepository and advance patient endotypingR21GM151703 · NIGMS · CINCINNATI CHILDRENS HOSP MED CTR · PI ATREYA, MIHIR R, KAMALESWARAN, RISHIKESAN · 2023 to 2024
$459k
Establishment of a multi-center biobank of patient-specific induced pluripotent stem cells for pediatric sepsis researchR21GM150093 · NIGMS · CINCINNATI CHILDRENS HOSP MED CTR · PI ATREYA, MIHIR R, LAUTZ, ANDREW JOHN · 2023 to 2024
$431k
NHLBI NIH HHS R01 HL152083NHLBI NIH HHS R35 HL161196NHLBI NIH HHS T32 HL129970NIAID NIH HHS U19 AI057229NIAID NIH HHS U19 AI167903NIGMS NIH HHS R21 GM150093NIGMS NIH HHS R21 GM151703NIGMS NIH HHS R35 GM155165
6 · The paper itself

Abstract

Progress in the management of critical care syndromes such as sepsis, Acute Respiratory Distress Syndrome (ARDS), and trauma has slowed over the last two decades, limited by the inherent heterogeneity within syndromic illnesses. Numerous immune endotypes have been proposed in sepsis and critical care, however the overlap of the endotypes is unclear, limiting clinical translation. The SUBSPACE consortium is an international consortium that aims to advance precision medicine through the sharing of transcriptomic data. By evaluating the overlap of existing immune endotypes in sepsis across over 6,000 samples, we developed cell-type specific signatures to quantify dysregulation in these immune compartments. Myeloid and lymphoid dysregulation were associated with disease severity and mortality across all cohorts. This dysregulation was not only observed in sepsis but also in ARDS, trauma, and burn patients, indicating a conserved mechanism across various critical illness syndromes. Moreover, analysis of randomized controlled trial data revealed that myeloid and lymphoid dysregulation is linked to differential mortality in patients treated with anakinra or corticosteroids, underscoring its prognostic and therapeutic significance. In conclusion, this novel immunology-based framework for quantifying cellular compartment dysregulation offers a valuable tool for prognosis and therapeutic decision-making in critical illness.

Identifiers

PMID39605502
PMCPMC11601436

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.