ArticlebioRxiv : the preprint server for biology2024
Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19.
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Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4citing papers in PubMed
–field-weighted citation impact
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Does Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Represent a Poly-Herpesvirus Post-Virus Infectious Disease?Viruses · 2025Review
- Advances in Epstein-Barr Virus Detection: From Traditional Methods to Modern Technologies.Viruses · 2025Review
- Genomic, socio-environmental, and sequencing capability patterns in the surveillance of SARS-CoV-2 in Latin America and the Caribbean up to 2023.Scientific reports · 2025Article
- The human plasma anellome exhibits age- and sex-dependent patterns with links to cardiometabolic health in older adults.Frontiers in microbiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
58 authors.
Cole MaguireThe University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0001-8986-9762
Jing ChenClinical and Data Coordinating Center (CDCC) Precision Vaccines Program, Boston Children's Hospital, Boston, MA 02115, USA.
Nadine RouphaelEmory School of Medicine, Atlanta, GA 30322, USA.
Harry PickeringDavid Geffen School of Medicine at the University of California Los Angeles, Los Angeles CA 90095, USA.
Hoang Van PhanUniversity of California San Francisco, San Francisco, CA 94115, USA.
Abigail GlascockChan Zuckerberg Biohub, San Francisco, CA 94158, USA.
Victoria ChuUniversity of California San Francisco, San Francisco, CA 94115, USA.
Ravi DandekarUniversity of California San Francisco, San Francisco, CA 94115, USA.
David CorryBaylor College of Medicine and the Center for Translational Research on Inflammatory Diseases, Houston, TX 77030, USA.
Farrah KheradmandBaylor College of Medicine and the Center for Translational Research on Inflammatory Diseases, Houston, TX 77030, USA.
Lindsey R BadenBrigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Rafick SelakyCase Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106, USA.
Grace A McComseyCase Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106, USA.
Elias K HaddadDrexel University, Tower Health Hospital, Philadelphia, PA 19104, USA.
Charles B CairnsDrexel University, Tower Health Hospital, Philadelphia, PA 19104, USA.
Bali PulendranStanford University School of Medicine, Palo Alto, CA 94305, USA.
Ana Fernandez-SesmaIcahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Viviana SimonIcahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Jordan P MetcalfOklahoma University Health Sciences Center, Oklahoma City, OK 73104, USA.
Nelson I Agudelo HiguitaOklahoma University Health Sciences Center, Oklahoma City, OK 73104, USA.
William B MesserOregon Health Sciences University, Portland, OR 97239, USA.
Mark M DavidStanford University School of Medicine, Palo Alto, CA 94305, USA.
Kari C NadeauStanford University School of Medicine, Palo Alto, CA 94305, USA.
Monica KraftUniversity of Arizona, Tucson AZ 85721, USA.
Chris BimeUniversity of Arizona, Tucson AZ 85721, USA.
Joanna SchaenmanDavid Geffen School of Medicine at the University of California Los Angeles, Los Angeles CA 90095, USA.
David ErleUniversity of California San Francisco, San Francisco, CA 94115, USA.
Carolyn S CalfeeUniversity of California San Francisco, San Francisco, CA 94115, USA.
Mark A AtkinsonUniversity of Florida, Gainesville, FL 32611, USA.
Scott C BrackenridgeUniversity of Florida, Gainesville, FL 32611, USA.
Lauren I R EhrlichThe University of Texas at Austin, Austin, TX 78712, USA.
Ruth R MontgomeryYale School of Medicine, New Haven, CT 06510, USA.
Albert C ShawYale School of Medicine, New Haven, CT 06510, USA.
Catherine L HoughOregon Health Sciences University, Portland, OR 97239, USA.
Linda N GengStanford University School of Medicine, Palo Alto, CA 94305, USA.
David A HaflerYale School of Medicine, New Haven, CT 06510, USA.
Alison D AugustineNational Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD 20814, USA.
Patrice M BeckerNational Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD 20814, USA.
Bjoern PetersLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Al OzonoffClinical and Data Coordinating Center (CDCC) Precision Vaccines Program, Boston Children's Hospital, Boston, MA 02115, USA.
Seunghee Hee Kim-SchulzeIcahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Florian KrammerIcahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Steve BosingerEmory School of Medicine, Atlanta, GA 30322, USA.
Walter EckalbarUniversity of California San Francisco, San Francisco, CA 94115, USA.
Matthew C AltmanBenaroya Research Institute, University of Washington, Seattle, WA 98101, USA.
Michael WilsonUniversity of California San Francisco, San Francisco, CA 94115, USA.
Leying GuanYale School of Public Health, New Haven, CT 06510, USA.
Steven H KleinsteinYale School of Medicine, New Haven, CT 06510, USA.
IMPACC Network
Kinga K SmolenPrecision Vaccines Program, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Elaine F ReedDavid Geffen School of Medicine at the University of California Los Angeles, Los Angeles CA 90095, USA.
Ofer LevyPrecision Vaccines Program, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Holden MaeckerStanford University School of Medicine, Palo Alto, CA 94305, USA.
Peter HuntUniversity of California San Francisco, San Francisco, CA 94115, USA.
Hanno SteenPrecision Vaccines Program, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Joann Diray-ArceClinical and Data Coordinating Center (CDCC) Precision Vaccines Program, Boston Children's Hospital, Boston, MA 02115, USA.
Charles R LangelierUniversity of California San Francisco, San Francisco, CA 94115, USA.
Esther MelamedThe University of Texas at Austin, Austin, TX 78712, USA.
Funding
Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5MTranslation of immunologic technologies from basic research into pre-clinical nonU19AI062629 · NIAID · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI COGGESHALL, KENNETH MARK · 2004 to 2023
$56.2MSystems investigation of vaccine responses in B cell depleted autoimmune patientsU19AI089992 · NIAID · YALE UNIVERSITY · PI Albert C Shaw · 2010 to 2026
$50.4MProject 3 - Ex vivo immune profiling of dengue viruses and vaccinesU19AI118610 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HARRIS, EVA · 2015 to 2021
$46.6MSystems Biological Analysis of Innate and Adaptive Responses to VaccinationU19AI090023 · NIAID · EMORY UNIVERSITY · PI AHMED, RAFI, LI, SHUZHAO · 2010 to 2021
$45.0MUnderstanding Asthma EndotypesU19AI077439 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2008 to 2026
$41.1MClinical and Translational Science Collaborative of Northern Ohio, Catalyzing Linkages to Equity in Health (CLE Health)UM1TR004528 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI GRACE A MCCOMSEY · 2023 to 2026
$32.1MTranscriptomics to define biomarkers of neonatal vaccine immunogenicityU19AI118608 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI LEVY, OFER · 2017 to 2021
$24.7MTollip inhibits IL-33 signaling during airway influenza virus infectionU19AI125357 · NIAID · UNIVERSITY OF ARIZONA · PI KRAFT, MONICA, VERCELLI, DONATA · 2016 to 2025
$14.7MProject 3: Mapping the Evolution of Chronic Transplant Injury in the Context of CMV InfectionU19AI128913 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REED, ELAINE F, SARWAL, MINNIE M · 2017 to 2021
$11.2MThe contribution of GPCRs to thymocyte medullary entry and central toleranceR01AI104870 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI Lauren Ilyse Richie EHRLICH · 2014 to 2026
$7.6MInvestigating the impact of helminth infection on microbioma composition and innate immunity generated during HepB vaccination. U19AI128910 · NIAID · DREXEL UNIVERSITY · PI HADDAD, ELIAS K · 2017 to 2021
$7.0MNCATS NIH HHS UM1 TR004528NIAID NIH HHS K23 AI185326NIAID NIH HHS R01 AI104870NIAID NIH HHS R01 AI122220NIAID NIH HHS R01 AI135803NIAID NIH HHS R01 AI145835NIAID NIH HHS U19 AI057229NIAID NIH HHS U19 AI062629NIAID NIH HHS U19 AI077439NIAID NIH HHS U19 AI089992NIAID NIH HHS U19 AI090023NIAID NIH HHS U19 AI118608NIAID NIH HHS U19 AI118610NIAID NIH HHS U19 AI125357NIAID NIH HHS U19 AI128910NIAID NIH HHS U19 AI128913NIAID NIH HHS U54 AI142766NIDA NIH HHS T32 DA018926
Abstract
Chronic viral infections are ubiquitous in humans, with individuals harboring multiple latent viruses that can reactivate during acute illnesses. Recent studies have suggested that SARS-CoV-2 infection can lead to reactivation of latent viruses such as Epstein-Barr Virus (EBV) and cytomegalovirus (CMV), yet, the extent and impact of viral reactivation in COVID-19 and its effect on the host immune system remain incompletely understood. Here we present a comprehensive multi-omic analysis of viral reactivation of all known chronically infecting viruses in 1,154 hospitalized COVID-19 patients, from the Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) study, who were followed prospectively for twelve months. We reveal significant reactivation of
Indexed as
AnellovirdaeChronic VirusCOVID-19CytomegalovirusEpstein-Barr VirusHerpesvirusesLong-COVIDPASCSimplexvirus
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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.