Evidence map›Paper›PMID 39605476›Full record

ArticlebioRxiv : the preprint server for biology2024

Targeted protein evolution in the gut microbiome by diversity-generating retroelements.

Benjamin R Macadangdang, Yanling Wang, Cora Woodward, Jessica I Revilla, Bennett M Shaw, Kayvan Sasaninia, Sara K Makanani, Chiara Berruto, Umesh Ahuja, Jeff F Miller

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Benjamin R MacadangdangDivision of Neonatology and Developmental Biology, Department of Pediatrics, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA, United States.
Yanling WangDepartment of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California, United States.
Cora WoodwardCalifornia NanoSystems Institute, Los Angeles, CA, United States.
Jessica I RevillaDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, United States.
Bennett M ShawDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Kayvan SasaniniaDepartment of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California, United States.
Sara K MakananiDepartment of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California, United States.
Chiara BerrutoDepartment of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California, United States.
Umesh AhujaCalifornia NanoSystems Institute, Los Angeles, CA, United States.
Jeff F MillerCalifornia NanoSystems Institute, Los Angeles, CA, United States.

Funding

Pediatric Scientist Development Program (PSDP) [K12]K12HD000850 · NICHD · YALE UNIVERSITY · PI Sallie R. Permar · 1987 to 2026
$44.1M
UCLA Child Health Research Career Development AwardK12HD111040 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Sherin U Devaskar, Shafali Spurling Jeste · 2023 to 2026
$1.2M
Diversity generation in the gastrointestinal microbiomeK08DK138316 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Benjamin Macadangdang · 2024 to 2026
$513k
NICHD NIH HHS K12 HD000850NICHD NIH HHS K12 HD111040NIDDK NIH HHS K08 DK138316
6 · The paper itself

Abstract

Diversity-generating retroelements (DGRs) accelerate evolution by rapidly diversifying variable proteins. The human gastrointestinal microbiota harbors the greatest density of DGRs known in nature, suggesting they play adaptive roles in this environment. We identified >1,100 unique DGRs among human-associated

Identifiers

PMID39605476
PMCPMC11601372

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.