Evidence map›Paper›PMID 39605466›Full record

ArticlebioRxiv : the preprint server for biology2024

Epigenetic modulation of NLRP6 inflammasome sensor as a therapeutic modality to reduce necroptosis-driven gastrointestinal mucosal dysfunction in HIV/SIV infection.

Lakmini S Premadasa, Marina McDew-White, Luis Romero, Beverly Gondo, Jade A Drawec, Binhua Ling, Chioma M Okeoma, Mahesh Mohan

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Lakmini S Premadasa
Marina McDew-White
Luis Romero
Beverly Gondo
Jade A Drawec
Binhua Ling
Chioma M OkeomaORCID 0000-0001-7737-6493
Mahesh Mohan

Funding

Texas Developmental Center for AIDS ResearchP30AI161943 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI RICE, ANDREW P · 2021 to 2025
$8.3M
Brain myeloid cell-targeted multiplexed gene editing for SIV/HIV eradicationR01MH130193 · NIMH · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Wenhui Hu, Binhua Julie Ling · 2022 to 2026
$4.0M
NIAID NIH HHS P30 AI161943NIMH NIH HHS R01 MH130193
6 · The paper itself

Abstract

The epigenetic mechanisms driving persistent gastrointestinal mucosal dysfunction in HIV/SIV infection is an understudied topic. Using reduced-representation bisulfite sequencing, we identified HIV/SIV infection in combination anti-retroviral therapy (cART)-naive rhesus macaques (RMs) to induce marked hypomethylation throughout promoter-associated CpG islands (paCGIs) in genes related to inflammatory response (

Identifiers

PMID39605466
PMCPMC11601347

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.