Evidence map›Paper›PMID 39605444›Full record

ArticlebioRxiv : the preprint server for biology2024

Genotype-immunophenotype relationships in

Morgan Drucker, Darren Lee, Xuan Zhang, Bailee Kain, Michael Bowman, Deedra Nicolet, Zhe Wang, Richard M Stone, Krzysztof Mrózek, Andrew J Carroll and 8 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Morgan DruckerDivision of Hematology/Oncology, Cancer & Blood Disease Institute, Cincinnati Children's Hospital Medical Center, Cincinnati OH USA.
Darren LeeUniversity of Cincinnati College of Medicine, Cincinnati OH USA.
Xuan ZhangDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati OH USA.
Bailee KainDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati OH USA.
Michael BowmanDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia PA USA.
Deedra NicoletThe Ohio State University Comprehensive Cancer Center, Columbus, OH USA.
Zhe WangDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati OH USA.
Richard M StoneDana-Farber/Partner CancerCare, Boston MA, USA.
Krzysztof MrózekThe Ohio State University Comprehensive Cancer Center, Columbus, OH USA.
Andrew J CarrollDepartment of Genetics, University of Alabama at Birmingham, Birmingham, AL USA.
Daniel T StarczynowskiDivision of Experimental Hematology & Cancer Biology, Cancer & Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati OH USA.
Ross L LevineHuman Oncology and Pathogenesis Program, Molecular Cancer Medicine Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
John C ByrdUniversity of Cincinnati Cancer Center, Cincinnati OH USA.
Ann-Kathrin EisfeldThe Ohio State University Comprehensive Cancer Center, Columbus, OH USA.
Nathan SalomonisDepartment of Pediatrics, University of Cincinnati, Cincinnati OH USA.ORCID 0000-0001-9689-2469
H Leighton GrimesDepartment of Pediatrics, University of Cincinnati, Cincinnati OH USA.ORCID 0000-0001-8162-6758
Robert L BowmanDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia PA USA.
Linde A MilesDivision of Experimental Hematology & Cancer Biology, Cancer & Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati OH USA.ORCID 0000-0003-3578-2842

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Training Program in Cancer TherapeuticsT32CA117846 · NCI · UNIVERSITY OF CINCINNATI · PI PRICE, CAROLYN M, TAKIAR, VINITA · 2006 to 2022
$6.5M
Post-Graduate Hematology/Oncology Translational (PG-HOT) Training ProgramT32CA236764 · NCI · UNIVERSITY OF CINCINNATI · PI QI, XIAOYANG, SCAGLIONI, PIER PAOLO · 2019 to 2023
$2.1M
Interrogating oncogene-dependency and mutation order in FLT3 mutant AMLR00CA248460 · NCI · UNIVERSITY OF PENNSYLVANIA · PI BOWMAN, ROBERT LYLE · 2022 to 2024
$743k
Dissecting the role of clonal evolution in NPM1-mutant AMLR00CA252005 · NCI · CINCINNATI CHILDRENS HOSP MED CTR · PI MILES, LINDE A · 2022 to 2024
$669k
NCI NIH HHS P30 CA008748NCI NIH HHS R00 CA248460NCI NIH HHS R00 CA252005NCI NIH HHS T32 CA117846NCI NIH HHS T32 CA236764
6 · The paper itself

Abstract

Acute myeloid leukemia (AML) is a multi-clonal disease, existing as a milieu of clones with unique but related genotypes as initiating clones acquire subsequent mutations. However, bulk sequencing cannot fully capture AML clonal architecture or the clonal evolution that occurs as patients undergo therapy. To interrogate clonal evolution, we performed simultaneous single cell molecular profiling and immunophenotyping on 43 samples from 32

Identifiers

PMID39605444
PMCPMC11601460

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.