Evidence map›Paper›PMID 39605420›Full record

ArticlebioRxiv : the preprint server for biology2025

Astrocytic modulation of population encoding in mouse visual cortex via GABA transporter 3 revealed by multiplexed CRISPR/Cas9 gene editing.

Jiho Park, Grayson O Sipe, Xin Tang, Prachi Ojha, Giselle Fernandes, Yi Ning Leow, Caroline Zhang, Yuma Osako, Arundhati Natesan, Gabrielle T Drummond and 2 more

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In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Jiho ParkDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, 01239, USA.
Grayson O SipeDepartment of Biology, Eberly College of Science and Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA.
Xin TangF.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Prachi OjhaPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Giselle FernandesPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Yi Ning LeowDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, 01239, USA.
Caroline ZhangDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, 01239, USA.
Yuma OsakoPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Arundhati NatesanPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Gabrielle T DrummondDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, 01239, USA.
Rudolf JaenischWhitehead Institute for Biomedical Research, Cambridge, MA, 02142, USA.
Mriganka SurDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, 01239, USA.

Funding

Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4M
Neuron-astrocyte mechanisms of norepinephrine in goal-directed learningR01MH133066 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MRIGANKA SUR · 2023 to 2026
$2.6M
Astrocyte-Neuron Circuits Underlying Cortical Mechanisms of Learned BehaviorR01NS130361 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MRIGANKA SUR · 2022 to 2026
$2.1M
Spatiotemporal dynamics of locus coeruleus circuits during learned behaviorR01MH126351 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SUR, MRIGANKA · 2021 to 2025
$2.1M
Novel tools for spatiotemporal modulation of astrocytes in neuronal circuitsRF1DA049005 · NIDA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SUR, MRIGANKA · 2019 to 2019
$1.5M
Role of glial glutamate transporters in V1 plasticity and developmentF32EY022264 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI PETRAVICZ, JEREMY C · 2012 to 2014
$163k
NEI NIH HHS F32 EY022264NICHD NIH HHS P50 HD105351NIDA NIH HHS RF1 DA049005NIMH NIH HHS R01 MH126351NIMH NIH HHS R01 MH133066NINDS NIH HHS R01 NS130361
6 · The paper itself

Abstract

Astrocytes, which are increasingly recognized as pivotal constituents of brain circuits governing a wide range of functions, express GABA transporter 3 (Gat3), an astrocyte-specific GABA transporter responsible for maintenance of extra-synaptic GABA levels. Here, we examined the functional role of Gat3 in astrocyte-mediated modulation of neuronal activity and information encoding. First, we developed a multiplexed CRISPR construct applicable for effective genetic ablation of Gat3 in the visual cortex of adult mice. Using

Identifiers

PMID39605420
PMCPMC11601534

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.