Evidence map›Paper›PMID 39605400›Full record

ArticlebioRxiv : the preprint server for biology2025

Mind the Gap: Does Brain Age Improve Alzheimer's Disease Prediction?

Trevor Wei Kiat Tan, Kim-Ngan Nguyen, Chen Zhang, Ru Kong, Susan F Cheng, Fang Ji, Joanna Su Xian Chong, Eddie Jun Yi Chong, Narayanaswamy Venketasubramanian, Csaba Orban and 5 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Trevor Wei Kiat TanCentre for Sleep and Cognition & Centre for Translational MR Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.ORCID 0000-0002-3732-4768
Kim-Ngan NguyenCentre for Sleep and Cognition & Centre for Translational MR Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.ORCID 0009-0004-5968-6307
Chen ZhangCentre for Sleep and Cognition & Centre for Translational MR Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.ORCID 0000-0002-1579-0047
Ru KongCentre for Sleep and Cognition & Centre for Translational MR Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.ORCID 0000-0001-7842-0329
Susan F ChengCentre for Sleep and Cognition & Centre for Translational MR Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.ORCID 0000-0002-1201-2880
Fang JiCentre for Sleep and Cognition & Centre for Translational MR Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.ORCID 0000-0002-7471-0115
Joanna Su Xian ChongCentre for Sleep and Cognition & Centre for Translational MR Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.ORCID 0009-0008-5077-5206
Eddie Jun Yi ChongMemory, Aging and Cognition Centre, National University Health System, Singapore.
Narayanaswamy VenketasubramanianRaffles Neuroscience Centre, Raffles Hospital, Singapore.ORCID 0000-0003-3593-6362
Csaba OrbanCentre for Sleep and Cognition & Centre for Translational MR Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.ORCID 0000-0001-9133-3561
Michael W L CheeCentre for Sleep and Cognition & Centre for Translational MR Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.ORCID 0000-0002-6087-0548
Christopher ChenMemory, Aging and Cognition Centre, National University Health System, Singapore.ORCID 0000-0002-1047-9225
Juan Helen ZhouCentre for Sleep and Cognition & Centre for Translational MR Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.ORCID 0000-0002-0180-8648
B T Thomas YeoCentre for Sleep and Cognition & Centre for Translational MR Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.ORCID 0000-0002-0119-3276
Australian Imaging Biomarkers and Lifestyle Study of Aging

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
A mega-analysis framework for delineating autism neurosubtypesR01MH133334 · NIMH · CHILD MIND INSTITUTE, INC. · PI Adriana Di Martino · 2023 to 2026
$2.9M
NIA NIH HHS U01 AG024904NIMH NIH HHS R01 MH133334
6 · The paper itself

Abstract

Brain age is widely regarded as a powerful marker of

Identifiers

PMID39605400
PMCPMC11601463

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.