ArticlebioRxiv : the preprint server for biology2025
Driving Forces of RNA Condensation Revealed through Coarse-Grained Modeling with Explicit Mg
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
RNAs are major drivers of phase separation in the formation of biomolecular condensates, and can undergo protein-free phase separation in the presence of divalent ions or crowding agents. Much remains to be understood regarding how the complex interplay of base stacking, base pairing, electrostatics, ion interactions, and particularly structural propensities governs RNA phase behavior. Here we develop an SIGNIFICANCE STATEMENT: Dynamic RNAs and proteins are major drivers of biomolecular phase separation that has been recently discovered to underlie numerous biological processes and be involved in many human diseases. Molecular simulation has an indispensable role to play in dissecting the driving forces and regulation of biomolecular phase separation. The current work describes a high-resolution coarse-grained RNA model that is capable of describing the structure dynamics and complex sequence, concentration, temperature and ion dependent phase transitions of flexible RNAs. The study further reveals a central role of RNA folding in coordinating Mg
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