Evidence map›Paper›PMID 39605351›Full record

ArticlebioRxiv : the preprint server for biology2025

Therapeutic benefits of maintaining CDK4/6 inhibitors and incorporating CDK2 inhibitors beyond progression in breast cancer.

Jessica Armand, Sungsoo Kim, Kibum Kim, Eugene Son, Minah Kim, Kevin Kalinsky, Hee Won Yang

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Jessica ArmandDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Sungsoo KimDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Kibum KimDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Eugene SonDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Minah KimDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Kevin KalinskyWinship Cancer Institute at Emory University, Department of Hematology and Medical Oncology, Atlanta, GA.
Hee Won YangDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA.ORCID 0000-0002-0000-8091

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
Angiopoietin-2/Tie2 signaling regulation of liver metastasis in pancreatic neuroendocrine tumorsR37CA266270 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Minah Kim · 2022 to 2026
$2.4M
Deciphering the mechanism of non-canonical cell cycle entryR01GM145884 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Hee Won Yang · 2023 to 2026
$1.4M
Deciphering Ang2/Tie2 signaling regulation of BBB disruption and neuroinflammation in Alzheimers diseaseR03AG073833 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KIM, MINAH · 2022 to 2022
$329k
NCI NIH HHS P30 CA013696NCI NIH HHS R37 CA266270NIA NIH HHS R03 AG073833NIGMS NIH HHS R01 GM145884
6 · The paper itself

Abstract

CDK4/6 inhibitors (CDK4/6i) with endocrine therapy are standard for hormone receptor-positive (HR

Identifiers

PMID39605351
PMCPMC11601343

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.