Evidence map›Paper›PMID 39605333›Full record

ArticlebioRxiv : the preprint server for biology2024

Conformational plasticity across phylogenetic clusters of RND multidrug efflux pumps and its impact on substrate specificity.

Mariya Lazarova, Thomas Eicher, Clara Börnsen, Hui Zeng, Mohd Athar, Ui Okada, Eiki Yamashita, Inga M Spannaus, Max Borgosch, Hi-Jea Cha and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Mariya LazarovaInstitute of Biochemistry, Goethe-University Frankfurt, Germany.
Thomas EicherInstitute of Biochemistry, Goethe-University Frankfurt, Germany.
Clara BörnsenBuchmann Institute for Molecular Life Sciences and Institute of Biophysics, Goethe-University Frankfurt, Germany.ORCID 0009-0002-5547-6789
Hui ZengInstitute of Biochemistry, Goethe-University Frankfurt, Germany.
Mohd AtharDepartment of Physics, University of Cagliari, Italy.
Ui OkadaDepartment of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.
Eiki YamashitaInstitute for Protein Research, Osaka University, Japan.
Inga M SpannausInstitute of Biochemistry, Goethe-University Frankfurt, Germany.
Max BorgoschInstitute of Biochemistry, Goethe-University Frankfurt, Germany.
Hi-Jea ChaInstitute of Biochemistry, Goethe-University Frankfurt, Germany.
Attilio V VargiuDepartment of Physics, University of Cagliari, Italy.
Satoshi MurakamiDepartment of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.ORCID 0000-0001-5553-7663
Kay DiederichsDepartment of Biology, University of Konstanz, Germany.ORCID 0000-0001-5360-0905
Achilleas S FrangakisBuchmann Institute for Molecular Life Sciences and Institute of Biophysics, Goethe-University Frankfurt, Germany.ORCID 0000-0002-4364-6202
Klaas M PosInstitute of Biochemistry, Goethe-University Frankfurt, Germany.ORCID 0000-0001-9035-3827

Funding

Optimization of efflux avoidance and inhibition for antibiotic developmentR01AI136799 · NIAID · UNIVERSITY OF OKLAHOMA · PI GNANAKARAN, SANDRASEGARAM, RUGGERONE, PAOLO · 2018 to 2022
$5.7M
NIAID NIH HHS R01 AI136799
6 · The paper itself

Abstract

Antibiotic efflux plays a key role for the multidrug resistance in Gram-negative bacteria

Identifiers

PMID39605333
PMCPMC11601597

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.