Evidence map›Paper›PMID 39605179›Full record

SynthesisDiabetes, obesity & metabolism2025

The effect of altered sleep timing on glycaemic outcomes: Systematic review of human intervention studies.

Romy Slebe, Jane J Splinter, Linda J Schoonmade, Denis P Blondin, David J T Campbell, André C Carpentier, Jean-Pierre Després, Joris Hoeks, Andries Kalsbeek, Parminder Raina and 7 more

Abstract readSystematic Review
In one paragraph

Synthesis in Diabetes, obesity & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Observational
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Romy SlebeEpidemiology and Data Science, Amsterdam UMC, location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0003-0455-5890
Jane J SplinterEpidemiology and Data Science, Amsterdam UMC, location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0009-0004-9163-2130
Linda J SchoonmadeUniversity Library, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-2407-5977
Denis P BlondinCentre de recherche du Centre hospitalier universitaire de Sherbrooke, Sherbrooke, Quebec, Canada.ORCID 0000-0001-6805-0985
David J T CampbellDepartment of Medicine, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada.ORCID 0000-0002-5570-3630
André C CarpentierCentre de recherche du Centre hospitalier universitaire de Sherbrooke, Sherbrooke, Quebec, Canada.ORCID 0000-0002-3983-8156
Jean-Pierre DesprésDepartment of Kinesiology, Université Laval and Centre de recherche sur les soins et les services de première ligne, Quebec, Canada.ORCID 0000-0002-5193-583X
Joris HoeksDepartment of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.ORCID 0000-0002-0265-0870
Andries KalsbeekDepartment of Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0001-9606-8453
Parminder RainaDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-8107-3193
Patrick SchrauwenDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-0973-847X
Mireille J SerlieDepartment of Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-8666-3379
Dirk Jan StenversAmsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands.ORCID 0000-0002-9519-5140
Chun-Xia YiAmsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands.ORCID 0000-0003-1184-4615
Renée de MutsertDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-5470-0673
Joline W J BeulensEpidemiology and Data Science, Amsterdam UMC, location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-4181-0937
Femke RuttersEpidemiology and Data Science, Amsterdam UMC, location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-1008-678X

Funding

CIHR TNC-174963Diabetes Fonds 2019.11.101Health~Holland LSHM20107ZonMw 459001021
6 · The paper itself

Abstract

aimsAlterations in sleep timing can lead to disturbances in glycaemic control, although the evidence is inconsistent. Therefore, this systematic review summarizes results from human intervention studies of altered sleep timing on glycaemic outcomes. MATERIALS AND

methodsAs part of a broader search on the effect of altering timing of sleep, physical activity and dietary intake, Medline and Embase were searched from inception to February 2023, and subsequent reference searches were done. With the help of a machine learning-aided program 'ASReview', we selected any type of intervention study in the general adult population, which acutely delayed sleep by ≥2 h for at least one night, while the total time in bed was the same between early and late sleep. Quality assessment was done using the quality assessment tool for quantitative studies.

resultsIn total, 14 studies (159 adults with normal or increased weight) were identified. Methodological quality was high (n = 4), moderate (n = 7) or low (n = 3). Acute delays of sleep onset showed unfavourable effects in 10 out of 27 measured glycaemic outcomes (one-six studies reported on each outcome) with outcomes mostly measured in the postprandial period, compared to (early) nighttime sleep.

conclusionsAcutely delaying sleep timing might have unfavourable effects on glycaemic outcomes, compared to (early) nighttime sleep. Future research does however need better controlled trials, also measuring and controlling sleep quantity, sleep quality, physical activity and dietary intake, with longer follow-up periods, consistent outcomes and designs and more diverse populations to provide targeted advice regarding the optimal timing for sleep. PROTOCOL REGISTRATION: This review is part of a larger search 'The effect of altering timing of physical activity, sleep and energy intake on glycaemia and Type 2 Diabetes risk in humans', of which the protocol was registered in the PROSPERO database on 27 November 2021 under number: CRD42021287828.

Indexed as

Blood GlucoseGlycemic ControlSleepAdultExerciseHumansTime FactorsBlood Glucosecircadian clockscircadian dysregulationglucose metabolismglycemic controlsleep

Identifiers

PMID39605179
PMCPMC11802402

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.