Evidence map›Paper›PMID 39605075›Full record

ArticleJournal of nanobiotechnology2024

Dendritic mesoporous silica-delivered siRNAs nano insecticides to prevent Sogatella furcifera by inhibiting metabolic detoxification and reproduction.

Changwei Gong, Wei Wang, Yanxin Ma, Xiaoxu Zhan, Anchun Peng, Jian Pu, Jizhi Yang, Xuegui Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Changwei GongState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Sichuan Agricultural University, Chengdu, 611130, China.
Wei WangCollege of Science, Sichuan Agricultural University, Chengdu, 611130, China. wwei@sicau.edu.cn.
Yanxin MaCollege of Agriculture, Sichuan Agricultural University, Chengdu, 611130, China.
Xiaoxu ZhanInstitute of Urban Agriculture, Chinese Academy of Agricultural Sciences, Chengdu, 611130, China.
Anchun PengCollege of Agriculture, Sichuan Agricultural University, Chengdu, 611130, China.
Jian PuCollege of Agriculture, Sichuan Agricultural University, Chengdu, 611130, China.
Jizhi YangCollege of Agriculture, Sichuan Agricultural University, Chengdu, 611130, China.
Xuegui WangState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Sichuan Agricultural University, Chengdu, 611130, China. wangxuegui@sicau.edu.cn.

Funding

the National Natural Science Foundation of China 22202049the Science & Technology Department of Sichuan Province 2024NSFSC1186the state key laboratory of crop gene exploration and utilization in southwest China SKL-ZY202221
6 · The paper itself

Abstract

backgroundMigratory insect infestation caused by Sogatella furcifera is a serious threat to rice production. The most effective method available for S. furcifera control is intensive insecticide spraying, which cause widespread resistance. RNA interference (RNAi) insecticides hold enormous potential in managing pest resistance. However, the instability and the poor efficiency of cross-kingdom RNA trafficking are key obstacles for the application in agricultural pest management.

methodsWe present dendritic mesoporous silica nanoparticles (DMSNs)-based nanocarrier for delivering siRNA and nitenpyram to inhibit the metabolic detoxification and development of S. furcifera, thereby preventing its proliferation.

resultsThis nano complex (denoted as N@UK-siRNA/DMSNs) significantly enhanced the stability of siRNA (efficacy lasting 21 days) and released cargos in GSH or planthopper bodily fluid with a maximum release rate of 84.99%. Moreover, the released UK-siRNA targeting two transcription factors (Ultraspiracle and Krüppel-homolog 1) downregulated the developmental genes Ultraspiracle (0.09-fold) and Krüppel-homolog 1 (0.284-fold), and downstream detoxification genes ABC SfABCH4 (0.016-fold) and P450 CYP6FJ3 (0.367-fold).

conclusionThe N@UK-siRNA/DMSNs inhibited pest development and detoxification, significantly enhancing susceptibility to nitenpyram to nanogram level (LC

Indexed as

HemipteraInactivation, MetabolicInsecticidesNanoparticlesRNA, Small InterferingSilicon DioxideAnimalsOryzaPorosityReproductionRNA InterferenceInsecticidesRNA, Small InterferingSilicon DioxideDendritic mesoporous silica nanoparticlesInsecticide resistance managementInsecticides deliveryRNAi pesticidesSogatella furcifera

Identifiers

PMID39605075
PMCPMC11600678

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.