Evidence map›Paper›PMID 39605074›Full record

ArticleInternational journal for equity in health2024

Is the diagnosis and treatment of depression gender-biased? Evidence from a population-based aging cohort in Sweden.

Amaia Bacigalupe, Unai Martín, Federico Triolo, Linnea Sjöberg, Therese Rydberg Sterner, Serhiy Dekhtyar, Laura Fratiglioni, Amaia Calderón-Larrañaga

Abstract read
In one paragraph

Article in International journal for equity in health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amaia BacigalupeDepartment of Sociology and Social Work. Social Determinants of Health and Demographic Change-OPIK Research Group, University of the Basque Country, UPV/EHU, Leioa, Spain. amaia.bacigalupe@ehu.eus.
Unai MartínDepartment of Sociology and Social Work. Social Determinants of Health and Demographic Change-OPIK Research Group, University of the Basque Country, UPV/EHU, Leioa, Spain.
Federico TrioloAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Linnea SjöbergAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Therese Rydberg SternerAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Serhiy DekhtyarAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Laura FratiglioniAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Amaia Calderón-LarrañagaAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAs compared to men, older women´s higher rates of depression diagnosis and antidepressant use are widely reported. We aimed to: a) explore whether there is a potential gender bias in the clinical diagnosis of depression and antidepressant prescription in an older population from Stockholm; and 2) analyze if such gender bias differs by patients' age and socioeconomic status.

methodsWe used data from the Swedish National Study on Aging and Care in Kungsholmen, SNAC-K (N = 2,941). We compared gender differences in: (a) clinical diagnosis of depression according to the Swedish National Patient Register (ICD-10 codes F32-F34; F412) ("register-based diagnosis"); (b) SNAC-K-based diagnosis of depression, partially gender-blind, using the Comprehensive Psychopathological Rating Scale (CPRS) and the DSM-IV-TR ("SNAC-K based diagnosis); and (c) antidepressant use (ATC code N06A). To analyze the magnitude of the gender bias in the register-based diagnosis of depression and in antidepressant use, and the role of potential moderating factors, prevalence ratios (PR) were calculated using Poisson regression models. Models were run separately by age and social class.

resultsWomen had a 63% higher probability of having a register-based diagnosis of depression (PR = 1.63[1.23-2.15]) and a 79% higher probability of using antidepressants (PR = 1.79[1.34-2.40]). No gender differences were observed in the SNAC-K-based diagnosis of depression. The gender differences in the register-based diagnosis were narrowed, although remained significant, after considering age, depressive symptoms, and health services use (PR = 1.44[1.10-1.88]), as well as the register-based diagnosis in the case of antidepressant use (PR = 1.31[1.04-1.64]). This gender bias was larger among the younger-old and the most advantaged social class.

conclusionA gender-bias was identified in the diagnosis and treatment of depression in older adults within the Swedish healthcare setting, which could imply that health services may be contributing to the medicalization of women's mental health. Gender-sensitive clinical and public health interventions are essential to reduce gender disparities in mental healthcare, also in old age.

Indexed as

Antidepressive AgentsDepressionAgedAged, 80 and overAgingCohort StudiesFemaleHumansMaleMiddle AgedRegistriesSex FactorsSexismSwedenAntidepressive AgentsAntidepressant useDepressionGender inequalitiesSocial inequalities

Identifiers

PMID39605074
PMCPMC11600552

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.