ArticleLipids in health and disease2024
Temporal changes in lipid concentrations and the prevalence of dyslipidemia among individuals with diabetes, prediabetes, and normal blood glucose from 2011 to 2015.
Article in Lipids in health and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed.
- Sleep variability and risk of type 2 diabetes mellitus: Mediating role of social participation in a national longitudinal cohort study.Medicine · 2026Article
- Nonlinear associations between the cholesterol, high-density lipoprotein, and glucose index and type 2 diabetes risk in Chinese prediabetic adults: a cohort study.Scientific reports · 2026Article
- Associations of cumulative exposure and dynamic trajectories of the triglyceride-total cholesterol-body weight index with new-onset cardiometabolic multimorbidity in middle-aged and older Chinese adults: evidence from a nationwide prospective cohort study.Cardiovascular diabetology · 2026Article
- Impact of control patterns for the atherogenic index of plasma and its obesity-associated indices on transitions in prediabetes glycemic status: results from the CHARLS national cohort study.Lipids in health and disease · 2026Observational
- Atherogenic index of plasma, high sensitivity C-reactive protein and incident diabetes among middle-aged and elderly adults in China: a national cohort study.Cardiovascular diabetology · 2025Article
- Unraveling the role of cumulative triglyceride-total cholesterol-body weight index in stroke development: evidence from the CHARLS cohort.Frontiers in medicine · 2025Article
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Abstract
backgroundDyslipidemia plays a pivotal role in the development of diabetes mellitus (DM) and other metabolic disorders. This study aimed to investigate the trends in lipid concentrations among Chinese participants with different blood glucose statuses-ranging from DM and prediabetes mellitus (pre-DM) to normal blood glucose levels-between 2011 and 2015. Additionally, this study sought to provide a comprehensive description of the potential temporal changes in the prevalence of dyslipidemia among these populations in China during this period.
methodsThe data for this study were derived from the China Health and Retirement Longitudinal Study (CHARLS), encompassing two time points in 2011 and 2015. The 2011 data sample included 11,408 participants aged 45 years and above, whereas the 2015 data sample included 12,224 participants within the same age range.
resultsIn this study, a comparative analysis of data from 2011 to 2015 revealed that individuals diagnosed with DM and pre-DM experienced significant decreases in total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) and a significant increase in high-density lipoprotein cholesterol (HDL-C) (P < 0.05). For participants with pre-DM, the levels of residual cholesterol (RC) significantly increased, whereas the levels of the atherogenic index of plasma (AIP) significantly decreased (P < 0.05). Among participants with normal blood glucose, there was a significant decrease in the levels of TC and LDL-C and a significant increase in the levels of triglycerides (TGs), RCs, and the AIP (P < 0.05). Between 2011 and 2015, the concentrations of TC, TG, LDL-C, RC, and AIP, both unadjusted and adjusted, were significantly higher in individuals with DM than in those with pre-DM and normal blood glucose, with the opposite being true for HDL-C. In 2015, the prevalence of dyslipidemia among participants with DM, pre-DM, and normal blood glucose was 36.56% (95% CI: 34.49%, 38.66%), 15.78% (95% CI: 14.93%, 16.67%), and 11.23% (95% CI: 10.17%, 12.36%), respectively. The results of the present study revealed a significant decrease in the incidence of dyslipidemia in urban areas between 2011 and 2015 (P < 0.05).
conclusionThis study revealed that the prevalence of dyslipidemia is greater among DM patients, particularly those in the 55-64 years age group. Notably, over the four-year observation period, lipid profiles improved among DM patients and pre-DM patients. However, TG levels remained elevated, especially in the 45-54 years age group.
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