Evidence map›Paper›PMID 39605028›Full record

ArticleTrials2024

A study protocol for a multi-country cluster randomized controlled trial of the impact of a multi-component One Health strategy to eliminate Opisthorchis viverrini and soil transmitted helminths in the Lower Mekong Basin.

Mary Lorraine Mationg, Archie C A Clements, Gail M Williams, Matthew Kelly, Donald E Stewart, Catherine A Gordon, Kinley Wangdi, Sirikachorn Tangkawattana, Apiporn T Suwannatrai, Vanathom Savathdy and 11 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Mary Lorraine MationgNational Centre for Epidemiology and Population Health, Australian National University, Canberra, Australia. mary.mationg@anu.edu.au.ORCID http://orcid.org/0000-0002-0161-419X
Archie C A ClementsQueen's University, Belfast, UK.
Gail M WilliamsSchool of Public Health, University of Queensland, Brisbane, Australia.
Matthew KellyNational Centre for Epidemiology and Population Health, Australian National University, Canberra, Australia.
Donald E StewartSchool of Medicine, Griffith University, Gold Coast, Australia.
Catherine A GordonQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Kinley WangdiCanberra University, Canberra, Australia.
Sirikachorn TangkawattanaFaculty of Veterinary Medicine, Khon Kaen University, Khon Kaen, Thailand.
Apiporn T SuwannatraiDepartment of Tropical Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Vanathom SavathdyLao Tropical and Public Health Institute, Vientiane, Lao PDR.
Visal KhieuNational Centre for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia.
Sangduan WannachartSwiss Tropical and Public Health Institute, Basel, Switzerland.
Suji Yoo O'ConnorNational Centre for Epidemiology and Population Health, Australian National University, Canberra, Australia.
Simon ForsythSchool of Public Health, University of Queensland, Brisbane, Australia.
Sean GannonQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Peter OdermattSwiss Tropical and Public Health Institute, Basel, Switzerland.
Donald P McManusQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Somphou Sayasone *Lao Tropical and Public Health Institute, Vientiane, Lao PDR.
Virak Khieu *National Centre for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia.
Banchob Sripa *Department of Tropical Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Darren J Gray *QIMR Berghofer Medical Research Institute, Brisbane, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOpisthorchis viverrini (OV) and soil-transmitted helminths (STH) are two of the most common helminths contributing to the Neglected Tropical Disease (NTDs) burden in the Lower Mekong Basin. Although mass drug administration is the cornerstone of control programs to reduce morbidity caused by these infections, this approach has limitations in preventing re-infections. Elimination requires additional measures such as reservoir host treatment, improved hygiene and health education to reinforce MDA's impact. This study aims to examine the impact of a scalable multi-component One Health Helminth Elimination program in the Lower Mekong Basin (HELM) that combines human praziquantel (PZQ) and albendazole (ALB) treatment with a program that includes the "Magic Glasses" and the "Lawa Model" interventions with health promotion at their core.

methodsThis study will employ a cluster randomized controlled trial (cRCT) in 18 rural communities (with sub-district or villages as cluster units) across Cambodia, Laos and Thailand. The control arm will receive one round of PZQ/ALB treatment, while in the intervention arm, multi-component HELM program will be implemented, which includes PZQ/ALB treatment together with the Magic Glasses and Lawa Model interventions. OV and STH infections levels will be evaluated in individuals aged 5-75 years at baseline and will be repeated at follow-up (12 months after the HELM intervention), using modified formalin ethyl-acetate concentration technique and quantitative PCR. The primary outcome of the study will be cumulative incidence of human OV and STH infections. Outcomes between the study arms will be compared using generalized linear mixed models, accounting for clustering. DISCUSSION: Evidence from this trial will quantify the impact of a multi-component One Health control strategy in interrupting Ov and STH infections in the Lower Mekong Basin.

trial registrationAustralian New Zealand Clinical Trials Registry (ANZCTR): ACTRN12622000353796. Prospectively registered 28 February 2022.

Indexed as

AlbendazoleAnthelminticsHelminthiasisOpisthorchiasisOpisthorchisPraziquantelSoilAdolescentAdultAnimalsCambodiaChildFemaleHealth PromotionHumansLaosAlbendazoleAnthelminticsPraziquantelSoilHealth educationIntegrated controlLawa ModelMagic GlassesMass drug administrationOpisthorchis viverriniRandomized controlled trialSoil-transmitted helminths

Identifiers

PMID39605028
PMCPMC11603964

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.