ArticleLipids in health and disease2024
Relationship between stroke and estimated glucose disposal rate: results from two prospective cohort studies.
Article in Lipids in health and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Changes in the estimated glucose disposal rate and cardiometabolic multimorbidity in middle-aged and older adults.Cardiovascular diabetology · 2026Article
- Estimated glucose disposal rate and cardiovascular risk in metabolically healthy adults: a nationwide prospective cohort study.Scientific reports · 2026Article
- Association of C-reactive protein/high-density lipoprotein cholesterol ratio with stroke in Chinese adults across different glycemic status.Lipids in health and disease · 2026Article
- Cumulative exposure to the estimated glucose disposal rate and incident stroke in individuals with cardiovascular-kidney-metabolic syndrome stages 0-4: 6-year longitudinal evidence from CHARLS.Cardiovascular diabetology · 2026Article
- Insulin resistance assessed by estimated glucose disposal rate and risk of coronary artery calcification in middle-aged participants without diabetes undergoing health check-ups.Frontiers in endocrinology · 2026Article
- Additive value of combining triglyceride-glucose index and estimated glucose disposal rate for incident stroke prediction across glycaemic-regulation subgroups: a prospective cohort of 5,789 Chinese adults.Cardiovascular diabetology · 2025Article
- Estimated glucose disposal rate and the dynamic transitions of cardiometabolic multimorbidity and all-cause mortality in prediabetes: a multistate trajectory analysis.Lipids in health and disease · 2025Article
- The association between insulin resistance assessed by estimated glucose disposal rate and stroke prevalence and mortality in non-diabetic people: evidence from two prospective cohorts.Diabetology & metabolic syndrome · 2025Article
- Assessing the Impact of Estimated Glucose Disposal Rate (eGDR) on Cognitive Function in Older Adults: A NHANES-Based Machine Learning Study.CNS neuroscience & therapeutics · 2025Article
- Associations between estimated glucose disposal rate and osteoarthritis risk in US adults: a cross-sectional study.BMC musculoskeletal disorders · 2025Observational
- Identifying risk factors and predicting stroke using Bayesian networks: Evidence from NHANES 2011-2020.Digital healthArticle
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9 authors.
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Abstract
backgroundInsulin resistance (IR) is a recognized contributor to stroke association, and the estimated glucose disposal rate (eGDR) is a dependable indicator of IR. However, the specific connections between eGDR, stroke prevalence, and overall mortality have not been thoroughly investigated. This study aimed to examine how eGDR correlates with stroke and overall death rate.
methodsThe study leveraged information from the National Health and Nutrition Examination Survey (NHANES) spanning from 2007 to 2016. To unravel the data, the team utilized logistic regression, cox proportional hazards models, and restricted cubic splines (RCS) Sensitivity analyses excluded participants with a stroke history within the previous two years. Results were validated through analysis of the China Health and Retirement Longitudinal Study (CHARLS).
resultsA higher eGDR is like a protective shield against strokes, with those in the top eGDR quartile exhibited a 60% reduction in stroke association (OR = 0.40, 95% CI, 0.22-0.73, P = 0.003). Additionally, a higher eGDR correlates with a lower overall death rate (HR = 0.71, 95% CI, 0.52-0.98, P = 0.037), particularly in individuals without a history of stroke. RCS analysis demonstrated that eGDR's influence on stroke association follows a non-linear pattern. Subgroup analysis revealed that the protective effect of eGDR was stronger in non-diabetic and non-hypertensive individuals.
conclusioneGDR is inversely related to both stroke association and mortality, affirming its utility as a predictive marker of stroke.
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