ArticleBMC public health2024
Global, regional, and national burden of gout in elderly 1990-2021: an analysis for the global burden of disease study 2021.
Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The association between the triglyceride-glucose index and serum uric acid: a systematic review and meta-analysis.BMC endocrine disorders · 2026Pooled it
- Impact of alcohol consumption on hyperuricemia and gout: a systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Article
- Antioxidant malic-acid-derived lipid nanoparticles delivering secretory uricase circRNA for hyperuricemia and complication management in mice.Nature communications · 2026Article
- The rising global burden of gout attributable to kidney dysfunction: a 30-year trend analysis and projections to 2036.Clinical rheumatology · 2026Article
- Early Improvement in Cardiac Autonomic Modulation After a Recreational Physical Training Program in Healthy Children.Pediatric cardiology · 2026Article
- Epidemiological trends and burden of gout in China and the European Union: a GBD 2023 and Mendelian randomization study.Clinical rheumatology · 2026Article
- Global trends in age at onset of gout, 1990-2023: a sex-stratified and forecast analysis of the Global Burden of Disease Study 2023.Clinical rheumatology · 2026Article
- Content, quality, and reliability of gout-related videos on TikTok and Bilibili: A cross-sectional study.Medicine · 2026Article
- The IL-17 pathway mediated by m6A-modified lncRNA H19: a new mechanism for Jianpi Qingre Tongluo Prescription in repressing inflammation and improving lipid metabolism in gout arthritis.Chinese medicine · 2026Article
- Machine learning based on systemic inflammation response index and risk of cardiovascular disease in gout: a retrospective study and clinical validation.Clinical rheumatology · 2026Article
- Relationship Between Comprehensive Inflammatory Indicators and Gout Risk: A Cross-sectional Study Based on NHANES 2015-2018.Endocrine, metabolic & immune disorders drug targets · 2026Article
- Observational
- Pear-shaped body types linked to lower risk of gout: genetic evidence from Mendelian randomization.International journal of obesity (2005) · 2025Article
- Comparison of Clinical Characteristics in Older-Onset and Common-Age-of-Onset Gout: A Prospective Gout Cohort Study.Drugs & aging · 2025Article
- Global, regional, and national burdens of low back pain in women of childbearing age from 1990 to 2021: an analysis based on the global burden of disease study 2021.BMC public health · 2025Article
- Prediction of Monosodium Urate Crystal Deposits in the First Metatarsophalangeal Joint Using a Decision Tree ModelCurrent medical imaging · 2025Article
- Burden, risk factors, and forecasts of gout in BRICS countries, 1990-2021: Insights from the Global Burden of Disease Study 2021.PloS one · 2025Article
- Mitochondrial Oxidative Stress and Vascular Remodeling in Uric Acid Nephropathy: Mechanistic Insights and Therapeutic Implications.International journal of nephrology and renovascular disease · 2025Review
- Disease burden and trends in gout for adolescents from 1990 to 2021, with projections to 2050 globally, in East Asia and China: results from the Global Burden of Disease study 2021.Frontiers in public health · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGout, an inflammatory arthritis, disproportionately affects the elderly due to hyperuricemia, leading to significant health-related quality of life impairments and escalating healthcare costs. However, a comprehensive global analysis focusing on the elderly population is needed to inform effective interventions.
methodsUtilizing data from the Global Burden of Disease Study 2021, this study assessed the prevalence, incidence, and Years Lived with Disability (YLDs) of gout among individuals aged ≥ 55 years in 204 countries from 1990 to 2021. We also evaluated the impact of high body mass index (BMI) and kidney dysfunction as key risk factors.
resultsThe study identified 37,230,366 cases of gout globally among the elderly, with an age-standardized prevalence rate of 2505.4 per 100,000 population. There was a notable increase in prevalence with an Estimated Annual Percentage Change (EAPC) of 1.08. Similarly, the age-standardized incidence and YLD rates increased, with EAPCs of 0.83 and 1.06, respectively. High-income regions, particularly Australasia and High-income North America, exhibited the highest rates, while Central Latin America and the Caribbean reported the lowest. Males had a higher burden of gout than females. High BMI and kidney dysfunction were significant contributors to YLDs, with their impact more pronounced in regions with higher Socio-Demographic Index (SDI).
conclusionThe study found a growing gout burden among the elderly, with substantial regional and gender disparities. It underscores the urgent need for targeted public health interventions, particularly in high SDI regions, to address modifiable risk factors like high BMI and kidney dysfunction and to curb the rising trend of gout prevalence and disability.
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