Evidence map›Paper›PMID 39604726›Full record

ArticleNature2025

Gut microbiota strain richness is species specific and affects engraftment.

Alice Chen-Liaw, Varun Aggarwala, Ilaria Mogno, Craig Haifer, Zhihua Li, Joseph Eggers, Drew Helmus, Amy Hart, Jan Wehkamp, Esi S N Lamousé-Smith and 17 more

Erratum issuedAbstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

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  13. Benchmarking shotgun metagenomics.Nature microbiology · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. The gut as a central hub for multi-organ crosstalk in aging.Cellular and molecular life sciences : CMLS · 2026
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors.

Alice Chen-LiawPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-3600-4674
Varun AggarwalaPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-5499-7745
Ilaria MognoPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Craig HaiferConcord Clinical School, University of Sydney, Sydney, New South Wales, Australia.
Zhihua LiPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Joseph EggersIcahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Drew HelmusDr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Amy HartJanssen R&D, Spring House, PA, USA.
Jan WehkampJanssen R&D, Spring House, PA, USA.
Esi S N Lamousé-SmithJanssen R&D, Spring House, PA, USA.
Robert L KerbyDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA.
Federico E ReyDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-0239-7780
Jean Frédéric ColombelDr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-6472-249X
Michael A KammDepartment of Gastroenterology and Medicine, St. Vincent's Hospital, Melbourne, Victoria, Australia.
Bernat OlleVedanta Biosciences, Cambridge, MA, USA.
Jason M NormanVedanta Biosciences, Cambridge, MA, USA.ORCID 0000-0001-5049-8415
Rajita MenonVedanta Biosciences, Cambridge, MA, USA.
Andrea R WatsonVedanta Biosciences, Cambridge, MA, USA.ORCID 0000-0003-0128-6795
Emily CrossetteVedanta Biosciences, Cambridge, MA, USA.ORCID 0000-0003-3645-2909
Elisabeth M TerveerNetherlands Donor Feces Bank, Leiden University Medical Center, Leiden, The Netherlands.
Josbert J KellerNetherlands Donor Feces Bank, Leiden University Medical Center, Leiden, The Netherlands.
Thomas J BorodyCentre for Digestive Diseases, Sydney, New South Wales, Australia.ORCID 0000-0002-0519-4698
Ari GrinspanDr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sudarshan ParamsothyConcord Clinical School, University of Sydney, Sydney, New South Wales, Australia.
Nadeem O KaakoushSchool of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia.ORCID 0000-0003-4017-1077
Marla C DubinskyDr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jeremiah J FaithPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. jeremiah.faith@mssm.edu.ORCID 0000-0002-2691-4500

Funding

Mount Sinai Medical Scientist Training ProgramT32GM146636 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Talia H Swartz · 2022 to 2026
$6.8M
The Influence Of Gut Microbiota Stability In Inflammatory Bowel DiseaseR01DK112978 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Jeremiah James Faith · 2019 to 2026
$5.3M
Determination of mucosal immune responses to, and infection of the gastrointestinal tract by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)R01DK123749 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CERUTTI, ANDREA, FAITH, JEREMIAH JAMES · 2020 to 2024
$4.9M
Uncovering the rules of gut microbiome strain transmissionR01DK124133 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Jeremiah James Faith · 2020 to 2026
$4.2M
Quantification of bacterial strain count in the human gut microbiome in health and diseaseF30DK131862 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHEN-LIAW, ALICE YULAN · 2022 to 2025
$199k
NIDDK NIH HHS F30 DK131862NIDDK NIH HHS R01 DK112978NIDDK NIH HHS R01 DK123749NIDDK NIH HHS R01 DK124133NIGMS NIH HHS T32 GM146636
6 · The paper itself

Abstract

Despite the fundamental role of bacterial strain variation in gut microbiota function

Indexed as

Fecal Microbiota TransplantationFecesGastrointestinal MicrobiomeSpecies SpecificityAnimalsBacteriaBiodiversityHumansLakesMetagenomeMiceSoil Microbiology

Identifiers

PMID39604726
PMCPMC12547691

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.