Evidence map›Paper›PMID 39604656›Full record

ReviewNature reviews. Microbiology2025

Shigella sonnei: epidemiology, evolution, pathogenesis, resistance and host interactions.

Timothy A Scott, Kate S Baker, Caroline Trotter, Claire Jenkins, Serge Mostowy, Jane Hawkey, Hayden Schmidt, Kathryn E Holt, Nicholas R Thomson, Stephen Baker

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Genome sequence ofMicrobiology resource announcements · 2026
    Article
  6. Article
  7. Emergence of a novel genotype of extensively drug-resistantAntimicrobial stewardship & healthcare epidemiology : ASHE · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Timothy A ScottCambridge Institute for Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Department of Medicine, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK. tas74@cam.ac.uk.ORCID http://orcid.org/0000-0001-7042-8609
Kate S BakerDepartment of Clinical Microbiology, Immunology and Infection, University of Liverpool, Liverpool, UK.
Caroline TrotterDepartment of Veterinary Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-4000-2708
Claire JenkinsUnited Kingdom Health Security Agency, London, UK.
Serge MostowyDepartment of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.ORCID http://orcid.org/0000-0002-7286-6503
Jane HawkeyDepartment of Infectious Diseases, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0001-9661-5293
Hayden SchmidtNeutralizing Antibody Center, International AIDS Vaccine Initiative, San Diego, CA, USA.
Kathryn E HoltDepartment of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.ORCID http://orcid.org/0000-0003-3949-2471
Nicholas R ThomsonDepartment of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.ORCID http://orcid.org/0000-0002-4432-8505
Stephen BakerCambridge Institute for Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Department of Medicine, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK. sgb47@cam.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Shigella sonnei is a major cause of diarrhoea globally and is increasing in prevalence relative to other Shigella because of multiple demographic and environmental influences. This single-serotype species has traditionally received less attention in comparison to Shigella flexneri and Shigella dysenteriae, which were more common in low-income countries and more tractable in the laboratory. In recent years, we have learned that Shigella are highly complex and highly susceptible to environmental change, as exemplified by epidemiological trends and increasing relevance of S. sonnei. Ultimately, methods, tools and data generated from decades of detailed research into S. flexneri have been used to gain new insights into the epidemiology, microbiology and pathogenesis of S. sonnei. In parallel, widespread adoption of genomic surveillance has yielded insights into antimicrobial resistance, evolution and organism transmission. In this Review, we provide an overview of current knowledge of S. sonnei, highlighting recent insights into this globally disseminated antimicrobial-resistant pathogen and assessing how novel data may impact future vaccine development and implementation.

Indexed as

Dysentery, BacillaryShigella sonneiAnti-Bacterial AgentsDrug Resistance, BacterialHumansAnti-Bacterial Agents

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.