Evidence map›Paper›PMID 39604654›Full record

ArticleActa neurochirurgica2024

Anterior selective targeting for radiosurgical treatment of trigeminal neuralgia: a cohort study.

Alperen Sozer, Ozan Yavuz Tufek, Merve Buke Sahin, Mustafa Caglar Sahin, Ozlem Dagli, Alp Ozgun Borcek, Hakan Emmez, Gokhan Kurt, Aydemir Kale, Sukru Aykol and 1 more

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In one paragraph

Article in Acta neurochirurgica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alperen SozerDepartment of Neurosurgery, Faculty of Medicine, Gazi University, Emniyet Mahallesi, Mevlana Bulvarı No: 29, Ankara, Turkey.
Ozan Yavuz TufekDepartment of Neurosurgery, Faculty of Medicine, Gazi University, Emniyet Mahallesi, Mevlana Bulvarı No: 29, Ankara, Turkey.
Merve Buke SahinMinistry of Health Kulu District Health Directorate, Konya, Turkey.
Mustafa Caglar SahinDepartment of Neurosurgery, Faculty of Medicine, Gazi University, Emniyet Mahallesi, Mevlana Bulvarı No: 29, Ankara, Turkey.
Ozlem DagliGamma Knife Unit, Department of Neurosurgery, Faculty of Medicine, Gazi University, Ankara, Turkey.
Alp Ozgun BorcekDepartment of Neurosurgery, Faculty of Medicine, Gazi University, Emniyet Mahallesi, Mevlana Bulvarı No: 29, Ankara, Turkey.
Hakan EmmezDepartment of Neurosurgery, Guven Hospital, Ankara, Turkey.
Gokhan KurtDepartment of Neurosurgery, Faculty of Medicine, Gazi University, Emniyet Mahallesi, Mevlana Bulvarı No: 29, Ankara, Turkey.
Aydemir KaleDepartment of Neurosurgery, Faculty of Medicine, Gazi University, Emniyet Mahallesi, Mevlana Bulvarı No: 29, Ankara, Turkey.
Sukru AykolDepartment of Neurosurgery, Faculty of Medicine, Gazi University, Emniyet Mahallesi, Mevlana Bulvarı No: 29, Ankara, Turkey.
Mesut Emre YamanDepartment of Neurosurgery, Faculty of Medicine, Gazi University, Emniyet Mahallesi, Mevlana Bulvarı No: 29, Ankara, Turkey. mesutemreyaman@gazi.edu.tr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveBefore commonly used targets such as the Retrogasserian Zone (RGZ) and the Root Entry Zone (REZ) were adopted for the radiosurgical treatment of trigeminal neuralgia (TN), a more anterior target involving the Gasserian ganglion was used. Thanks to advancements in imaging technology, it is now possible to identify and target separate nerve divisions in Meckel's Cave as desired. Although this approach has been mentioned previously, no clinical study has investigated it until now. This study aims to fill this gap in the literature.

methodsTrigeminal neuralgia patients who received radiosurgical treatment between February 2019 and June 2022 in a single centre were included in the study. Pain relief, medication dependency and side effect profiles of the investigated anterior selective target (AST) were compared to those of the classical targets at 1 week, 1-3-6 months, and 1 year.

resultsA total of 66 patients were included in the study. Effectiveness, safety and application convenience parameters were compared between; the REZ (n = 21), RGZ (n = 20) and AST (n = 25) groups. All groups showed significant improvement in pain with similar results to each other. AST treatments were performed in significantly shorter beam-on-times and with significantly lower brainstem doses.

conclusionsThe investigated AST showed comparable results to the classical targets without any indication of superiority or inferiority in terms of efficacy and safety in this preliminary investigation. As no blocks were needed to protect the brainstem with this method, it can be used for select patients as needed and could even be investigated in larger studies as an alternative approach.

Indexed as

RadiosurgeryTrigeminal NeuralgiaAdultAgedAged, 80 and overCohort StudiesFemaleHumansMaleMiddle AgedTreatment OutcomeTrigeminal GanglionFacial painGamma knife radiosurgeryStereotactic radiosurgeryTrigeminal neuralgia

Identifiers

PMID39604654

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.