Evidence map›Paper›PMID 39604628›Full record

ArticleEye (London, England)2025

Intersession repeatability of visual function and OCTA metrics in eyes with diabetic macular ischaemia.

Sridevi Thottarath, Wei-Shan Tsai, Sarega Gurudas, Elizabeth Pearce, Chui Ming Gemmy Chueng, Taffeta Ching Ning Yamaguchi, Sobha Sivaprasad

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Article in Eye (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Sridevi ThottarathNational Institute of Health Research Moorfields Biomedical Research Centre and Clinical Research Facility, Moorfields Eye Hospital, London, UK.
Wei-Shan TsaiNational Institute of Health Research Moorfields Biomedical Research Centre and Clinical Research Facility, Moorfields Eye Hospital, London, UK.ORCID http://orcid.org/0000-0001-5945-9316
Sarega GurudasNational Institute of Health Research Moorfields Biomedical Research Centre and Clinical Research Facility, Moorfields Eye Hospital, London, UK.
Elizabeth PearceInstitute of Ophthalmology, University College London, London, UK.
Chui Ming Gemmy ChuengSingapore National Eye Centre, Singapore, Singapore.
Taffeta Ching Ning YamaguchiBoehringer Ingelheim International GmbH, Binger Straße 173 | 55216 Ingelheim am Rhein, Germany.
Sobha SivaprasadNational Institute of Health Research Moorfields Biomedical Research Centre and Clinical Research Facility, Moorfields Eye Hospital, London, UK. sobha.sivaprasad@nhs.net.ORCID http://orcid.org/0000-0001-8952-0659

Funding

Boehringer Ingelheim SIVS 1048
6 · The paper itself

Abstract

objectiveTo estimate inter-session coefficient of repeatability (CR) of visual function and OCTA metrics over 3 months in diabetic macular ischaemia (DMI) in stable laser-treated proliferative diabetic retinopathy (PDR) patients.

methodsThis prospective study recruited patients with stable PDR for at least 6 months following pan-retinal photocoagulation with visual acuity of at least 54 ETDRS letters. DMI was confirmed on OCTA as FAZ area of at least 0.5 mm

results88 eligible eyes of 63 participants were included in the analysis. The CR for best corrected visual acuity (BCVA) was 10.1 ETDRS letters (95% CI 8.5-11.7 ETDRS letters), and for low luminance visual acuity (LLVA) was 12.4 letters (95% CI 10.4-14.4). The ICC for BCVA and LLVA was 0.81 and 0.75 respectively. For Square Root of Foveal Avascular Zone (SQRT-FAZ) area, CR and ICC was 0.043 mm and 1.00 respectively. The Bland-Altman plots suggest that the level of agreement is wider for vascular density (VD) metrics compared to FAZ parameters.

conclusionWe recommend using the FAZ metrics for quantitative measurements of DMI outcomes due to the excellent repeatability of manually corrected FAZ area.

Indexed as

Diabetic RetinopathyIschemiaMacula LuteaTomography, Optical CoherenceVisual AcuityAgedFemaleFluorescein AngiographyHumansLaser CoagulationMaleMiddle AgedProspective StudiesReproducibility of ResultsRetinal Vessels

Identifiers

PMID39604628
PMCPMC11933375

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.