ArticleNature communications2024
Population genomics of Plasmodium ovale species in sub-Saharan Africa.
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Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Rapid whole-genome sequencing of Plasmodium DNA from cryptic malaria cases in UK travellers provides insights into infection origins, transmission and antimalarial resistance.Journal of travel medicine · 2026Article
- Population genomics of Plasmodium malariae from 4 African countries.JCI insight · 2026Article
- Towards an evolutionary baseline model ofbioRxiv : the preprint server for biology · 2025Article
- Immunogenicity and gene polymorphism analysis of Plasmodium ovale wallikeri glycosylphosphatidylinositol-anchored micronemal antigen (GAMA).Malaria journal · 2025Article
- Metagenomic complexity of high, seasonal transmission of Plasmodium spp. in asymptomatic carriers in Northern Sahelian Ghana.Communications medicine · 2025Article
- Metagenomic analysis reveals extreme complexity ofmedRxiv : the preprint server for health sciences · 2025Article
- Population genomics of Plasmodium ovale species in sub-Saharan Africa.Nature communications · 2024Article
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Authors and funding
25 authors.
Kelly Carey-EwendDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA. kelly_carey-ewend@med.unc.edu.ORCID 0000-0002-3200-1644
Zachary R Popkin-HallInstitute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-8308-5294
Alfred SimkinDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.
Meredith MullerInstitute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC, USA.
Chris HennellyInstitute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC, USA.
Wenqiao HeInstitute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC, USA.
Kara A MoserInstitute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC, USA.
Claudia GaitherInstitute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC, USA.
Karamoko NiaréDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.
Farhang AghakanianInstitute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC, USA.
Sindew FelekeEthiopian Public Health Institute, Addis Ababa, Ethiopia.ORCID 0000-0002-5778-653X
Bokretsion G BrhaneEthiopian Public Health Institute, Addis Ababa, Ethiopia.
Fernandine PhanzuSANRU Asbl, Kinshasa, Democratic Republic of the Congo.
Melchior Mwandagalirwa KashamukaKinshasa School of Public Health, Kinshasa, Democratic Republic of the Congo.
Ozkan AydemirProgram in Molecular Medicine, Chan Medical School, University of Massachusetts, Worcester, MA, USA.ORCID 0000-0002-3458-6527
Colin J SutherlandLondon School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0003-1592-6407
Deus S IshengomaNational Institute for Medical Research (NIMR), Dar es Salaam, Tanzania.
Innocent M AliDepartment of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.ORCID 0000-0002-1112-6376
Billy NgasalaMuhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Albert KalonjiSANRU Asbl, Kinshasa, Democratic Republic of the Congo.
Antoinette TshefuKinshasa School of Public Health, Kinshasa, Democratic Republic of the Congo.
Jonathan B ParrInstitute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-4465-9830
Jeffrey A BaileyDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.ORCID 0000-0002-6899-8204
Jonathan J JulianoDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-0591-0850
Jessica T LinInstitute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC, USA.
Funding
Visualizing of Immune Responses to Toxoplasma GondiiR01AI065537 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI ROBEY, ELLEN A · 2005 to 2019
$5.1MTraining in Infectious Disease Epidemiology (TIDE)T32AI070114 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Brian W Pence · 2007 to 2026
$4.0MRDT-undetectable Malaria in the DR Congo: Epidemiology and Development of AlternativesR01AI132547 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DINGLASAN, RHOEL DAVID RAMOS, JULIANO, JONATHAN J · 2018 to 2022
$3.6MRelapsing malaria in Africa: mechanisms for persistence amid falciparum declineR01AI165537 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Rhoel David Ramos Dinglasan, Jonathan J Juliano · 2022 to 2026
$3.6MDeterminants of malaria transmission by submicroscopic gametocytemiaR01AI137395 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIN, JESSICA · 2018 to 2022
$3.3MCollaborative Research: Impacts of the African Origin of Plasmodium vivax on Contemporary Parasite PopulationsR01TW010870 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JULIANO, JONATHAN J · 2017 to 2021
$2.4MMentoring in Translational Malaria GenomicsK24AI134990 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jonathan J Juliano · 2018 to 2026
$1.6MA longitudinal epidemiological and epidemiological study of malaria and its vectors in the Kinshasa provinceR01AI129812 · NIAID · KINSHASA SCHOOL OF PUBLIC HEALTH · PI TSHEFU, ANTOINETTE KITOTO · 2017 to 2021
$674kDevelopment of novel diagnostics for African non-falciparum malariaR21AI148579 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIN, JESSICA, PARR, JONATHAN BOYD · 2020 to 2021
$420kPlasmodium ovale hypnozoite development and relapse: a coordinated in vivo in vitro studyR21AI152260 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ADAMS, JOHN H, LIN, JESSICA · 2021 to 2022
$418kPopulation genomics and relapse epidemiology of Plasmodium ovale in sub-Saharan AfricaF30AI179111 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Kelly Carey-Ewend · 2024 to 2026
$144kFIC NIH HHS R01 TW010870NIAID NIH HHS F30 AI179111NIAID NIH HHS K24 AI134990NIAID NIH HHS R01 AI065537NIAID NIH HHS R01 AI129812NIAID NIH HHS R01 AI132547NIAID NIH HHS R01 AI137395NIAID NIH HHS R01 AI165537NIAID NIH HHS R21 AI148579NIAID NIH HHS R21 AI152260NIAID NIH HHS T32 AI070114U.S. Department of Health & Human Services | National Institutes of Health (NIH) K24AI134990U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AI129812U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AI132547U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AI65537U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01TW010870U.S. Department of Health & Human Services | National Institutes of Health (NIH) R21AI148579U.S. Department of Health & Human Services | National Institutes of Health (NIH) R21AI152260U.S. Department of Health & Human Services | National Institutes of Health (NIH) T32AI070114
Abstract
Plasmodium ovale curtisi (Poc) and Plasmodium ovale wallikeri (Pow) are relapsing malaria parasites endemic to Africa and Asia that were previously thought to represent a single species. Amid increasing detection of ovale malaria in sub-Saharan Africa, we present a population genomic study of both species across the continent. We conducted whole-genome sequencing of 25 isolates from Central and East Africa and analyzed them alongside 20 previously published African genomes. Isolates are predominantly monoclonal (43/45), with their genetic similarity aligning with geography. Pow shows lower average nucleotide diversity (1.8×10
Indexed as
Genome, ProtozoanMalariaPlasmodium ovaleAfrica South of the SaharaGenetic VariationGenomicsHumansMerozoite Surface Protein 1MetagenomicsPhylogenyTetrahydrofolate DehydrogenaseWhole Genome SequencingMerozoite Surface Protein 1Tetrahydrofolate Dehydrogenase
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