Article in Schizophrenia (Heidelberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
6 authors.
Takato Honda *The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusettes Institute of Technology (MIT), Cambridge, MA, USA. takatoh@mit.edu.ORCID http://orcid.org/0000-0002-3327-8282
Kazuki Kurita *Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan.
Yuko AraiLife and Environmental Sciences, University of Tsukuba, Tsukuba, Japan.
Himani PandeyLife and Environmental Sciences, University of Tsukuba, Tsukuba, Japan.
Akira SawaDepartments of Psychiatry, Neuroscience, Mental Health, Pharmacology, Biomedical Engineering and Genetic Medicine, Johns Hopkins University School of Medicine and Bloomberg School of Public Health, Johns Hopkins Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-1401-3008
Katsuo Furukubo-TokunagaLife and Environmental Sciences, University of Tsukuba, Tsukuba, Japan.
Funding
Project 3P50MH094268 · NIMH · JOHNS HOPKINS UNIVERSITY · PI LEEK, JEFFREY T. · 2011 to 2020
$19.9M
Project 3P50MH136297 · NIMH · JOHNS HOPKINS UNIVERSITY · PI Akira Sawa · 2024 to 2026
$12.8M
Research Center for Molecular Pathogenesis of SchizophreniaP20MH084018 · NIMH · JOHNS HOPKINS UNIVERSITY · PI GALLAGHER, MICHAELA · 2008 to 2010
$3.3M
Nuclear pathway of DISC1 in major mental illnesses: biochemistry and cell biologyR01MH069853 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2004 to 2012
$3.2M
DISC1-dependent defects in neural fate, corticogenesis and cognition in psychosisR01MH105660 · NIMH · JOHNS HOPKINS UNIVERSITY · PI ISHIZUKA, KOKO, SAWA, AKIRA · 2014 to 2018
$2.8M
Deep Brain Stimulation for Chronic Auditory Hallucinations in Treatment-Resistant Schizophrenia: an early-stage clinical trialU01MH130625 · NIMH · JOHNS HOPKINS UNIVERSITY · PI CASCELLA, NICOLA G · 2023 to 2025
$2.3M
Oxidative stress and schizophrenia: combination of cell biology and brain imagingR01MH092443 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2011 to 2015
$1.8M
Defining of Neurodevelopmental Pathways Regulated by Neuregulin- DISC1 InteractioRC1MH088753 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ANTON, EVA S, SAWA, AKIRA · 2009 to 2010
$933k
PICK1 knockout mice: role for D-serine in neonatal forebrainsR21MH085226 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2010 to 2011
$369k
MEXT | Japan Society for the Promotion of Science (JSPS) 15J06369, Overseas Research FellowshipMEXT | Japan Society for the Promotion of Science (JSPS) Grants-in-Aid for Scientific Research 17K07041NIMH NIH HHS P20 MH084018NIMH NIH HHS P50 MH094268NIMH NIH HHS P50 MH136297NIMH NIH HHS R01 MH069853NIMH NIH HHS R01 MH092443NIMH NIH HHS R01 MH105660NIMH NIH HHS R21 MH085226NIMH NIH HHS RC1 MH088753NIMH NIH HHS U01 MH130625Uehara Memorial Foundation Overseas Research Fellowship
6 · The paper itself
Abstract
Synaptic development and functions have been hypothesized as crucial mechanisms of diverse neuropsychiatric disorders. Studies in past years suggest that mutations in the fragile X mental retardation 1 (FMR1) are associated with diverse mental disorders including intellectual disability, autistic spectrum disorder, and schizophrenia. In this study, we have examined genetical interactions between a select set of risk factor genes using fruit flies to find that dfmr1, the Drosophila homolog of the human FMR1 gene, exhibits functional interactions with DISC1 in synaptic development. We show that DISC1 overexpression in the dfmr1
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
FMR1 genetically interacts with DISC1 to regulate glutamatergic synaptogenesis. · full record | OpenQuestion