Evidence map›Paper›PMID 39604309›Full record

ArticleMovement disorders clinical practice2025

Characterizing Hand Function in Parkinson's Disease Patients with a Self-Administered Electronic Manual Dexterity Test.

A Elizabeth Jansen, Anson B Rosenfeldt, Cielita Lopez-Lennon, Hubert Fernandez, Eric Zimmerman, Peter B Imrey, Leland E Dibble, Jay L Alberts

Registry-linked trialAbstract read
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In one paragraph

Article in Movement disorders clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04000360 (Pragmatic Cyclical Lower Extremity Exercise Trial for Parkinson's Disease), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04000360 nacompletednot on this map

Pragmatic Cyclical Lower Extremity Exercise Trial for Parkinson's Disease

TypeinterventionalSponsorThe Cleveland ClinicRan2019 to 2023Enrolled256ConditionsParkinson DiseaseArmsHigh-Intensity Aerobic Exercise (AE), Usual and Customary Care (UCC)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

A Elizabeth JansenDepartment of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0003-3665-0374
Anson B RosenfeldtDepartment of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0001-5468-8208
Cielita Lopez-LennonDepartment of Physical Therapy and Athletic Training, University of Utah, Salt Lake, Utah, USA.ORCID https://orcid.org/0000-0001-7438-6733
Hubert FernandezCenter for Neurological Restoration, Cleveland Clinic, Cleveland, Ohio, USA.
Eric ZimmermanCenter for Neurological Restoration, Cleveland Clinic, Cleveland, Ohio, USA.
Peter B ImreyDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio, USA.
Leland E DibbleDepartment of Physical Therapy and Athletic Training, University of Utah, Salt Lake, Utah, USA.
Jay L AlbertsDepartment of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio, USA.

Funding

The Cyclical Lower-extremity Exercise for Parkinson's TrialR01NS073717 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI ALBERTS, JAY L. · 2011 to 2023
$4.8M
NIH HHS 2 R01 NS073717-06A1NINDS NIH HHS R01 NS073717
6 · The paper itself

Abstract

backgroundDexterous dysfunction is a bothersome patient-reported symptom of Parkinson's disease (PD). Current clinical assessments do not directly evaluate goal-directed hand function. This project sought to determine the capability of the electronic Manual Dexterity Test (MDT) to characterize dexterity across a range of PD patients.

objectivesTo objectively quantify manual dexterity in individuals with PD using a self-administered manual dexterity test.

methodsTwo hundred and forty-nine PD patients completed trials of the MDT with each upper extremity (UE) both while ON and OFF antiparkinsonian medication. Differences in MDT by medication state, more vs less affected UE, and Hoehn and Yahr (H&Y) stage were evaluated using linear mixed models. The relationships of trial duration to MDS-UPDRS II patient quality of life (QoL) questions for eating, dressing and hygiene were also evaluated.

resultsMDT duration was significantly shorter ON medication (26.3 seconds) compared to OFF medication (27.2 seconds) (P < 0.001). Similarly, MDT duration was significantly shorter for less (25.8 seconds) compared to more (27.6 seconds) affected limb (P < 0.001). Trial durations increased with H&Y stage (P < 0.001 for trend). MDT performance was related to MDS-UPDRS II questions for eating, dressing, and hygiene performance (P < 0.001).

conclusionsThe MDT provides an objective and quantitative assessment of dexterity. The time to complete the MDT was sensitive to changes in medication state, more and less affected UE, disease severity, and important activities of daily living. The MDT has potential for utilization in precise tracking of manual dexterity over the course of PD.

Indexed as

HandMotor SkillsParkinson DiseaseAgedAged, 80 and overAntiparkinson AgentsFemaleHumansMaleMiddle AgedQuality of LifeSeverity of Illness IndexAntiparkinson Agentshand functionParkinson's disease

Identifiers

PMID39604309
PMCPMC11952952

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