ArticleCNS spectrums2024
Correlating clinical course with baseline subcortical shape in provisional tic disorder.
Tiffanie Che, Soyoung Kim, Deanna J Greene, Ashley Heywood, Jimin Ding, Tamara Hershey, Bradley L Schlaggar, Kevin J Black, Lei Wang
Abstract read
In one paragraphArticle in CNS spectrums, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
9 authors.
Tiffanie CheDepartment of Psychiatry and Behavioral Health, Ohio State University Wexner Medical Center, Columbus, OH, USA.ORCID 0000-0002-6663-8248 Soyoung KimDepartments of Psychiatry and Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Deanna J GreeneDepartment of Cognitive Science, University of California San Diego, La Jolla, CA, USA.
Ashley HeywoodDepartment of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Jimin DingDepartment of Mathematics and Statistics; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Tamara HersheyDepartments of Psychiatry, Neurology, Psychological and Brain Sciences and Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Bradley L SchlaggarKennedy Krieger Institute, Baltimore, MD, USA.
Kevin J BlackDepartments of Psychiatry, Neurology, Radiology and Neuroscience, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-6921-9567 Lei WangDepartment of Psychiatry and Behavioral Health, Ohio State University Wexner Medical Center, Columbus, OH, USA.
Funding
Washington University Institute of Clinical and Translational Sciences (UL1)UL1RR024992 · NCRR · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2007 to 2011
$45.4MWashington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4MWashington University Intellectual and Developmental Disabilities Research Center-Administrative Down Syndrome SupplementU54HD087011 · NICHD · WASHINGTON UNIVERSITY · PI CONSTANTINO, JOHN N. · 2015 to 2019
$7.1MNeurocognitive Impact of Hypoglycemia in type 1 DiabetesR01DK064832 · NIDDK · WASHINGTON UNIVERSITY · PI HERSHEY, TAMARA G · 2003 to 2020
$6.0MTRACKING NEURODEGENERATION IN EARLY WOLFRAM SYNDROMER01HD070855 · NICHD · WASHINGTON UNIVERSITY · PI HERSHEY, TAMARA G · 2012 to 2022
$5.6MThe New Tics Study: A Novel Approach to Pathophysiology and Cause of Tic DisordersR01MH104030 · NIMH · WASHINGTON UNIVERSITY · PI BLACK, KEVIN J · 2017 to 2021
$3.3MLongitudinal Study of Brain Imaging and Cognitive Markers of Tourette Syndrome in ChildrenR01MH118217 · NIMH · WASHINGTON UNIVERSITY · PI GREENE, DEANNA JACQUELYN · 2019 to 2025
$3.2MNeurodegenerative and Neurodevelopmental Subcortical Shape DiffeomorphometryR01EB020062 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI MILLER, MICHAEL I, MOSTOFSKY, STEWART H · 2016 to 2019
$2.8MUnilateral Hearing Loss in ChildrenK23DC006638 · NIDCD · WASHINGTON UNIVERSITY · PI LIEU, JUDITH EUNKYUNG CHO · 2005 to 2009
$886kTraining New Investigators in Neuroimaging and in the Neuropsychiatry of MovementK24MH087913 · NIMH · WASHINGTON UNIVERSITY · PI BLACK, KEVIN J · 2010 to 2014
$818kPREDICTING OUTCOME IN CHILDREN WITH TIC DISORDERS USING NEUROIMAGING DATAK01MH104592 · NIMH · WASHINGTON UNIVERSITY · PI GREENE, DEANNA JACQUELYN · 2014 to 2018
$723kPREDICTING OUTCOME IN CHILDREN WITH NEW-ONSET TICS USING NEUROIMAGING DATAR21NS091635 · NINDS · WASHINGTON UNIVERSITY · PI BLACK, KEVIN J, SCHLAGGAR, BRADLEY L · 2015 to 2016
$419kEunice Kennedy Shriver National Institute of Child Health and Human Development K23DC006638Eunice Kennedy Shriver National Institute of Child Health and Human Development U54HD087011McDonnell Center for Systems NeuroscienceNational Institute of Child Health and Human Development R01HD070855National Science Foundation 1636893National Science Foundation 1734853NCATS NIH HHS UL1 TR000448NCRR NIH HHS UL1 RR024992NIBIB NIH HHS R01 EB020062NICHD NIH HHS R01 HD070855NICHD NIH HHS U54 HD087011NIDCD NIH HHS K23 DC006638NIDDK NIH HHS R01 DK064832NIDDK NIH HHS R01DK064832NIMH NIH HHS K01 MH104592NIMH NIH HHS K01MH104592NIMH NIH HHS K24 MH087913NIMH NIH HHS K24MH087913NIMH NIH HHS R01 MH104030NIMH NIH HHS R01MH104030NIMH NIH HHS R01 MH118217NIMH NIH HHS R01MH118217NINDS NIH HHS R21 NS091635NINDS NIH HHS R21NS091635
6 · The paper itselfAbstract
objectiveThis study examined children at the onset of tic disorder (tics for less than 9 months: NT group), a population on which little research exists. Here, we investigate relationships between the baseline shape and volume of subcortical nuclei, diagnosis, and tic symptom outcomes.
methods187 children were assessed at baseline and a 12-month follow-up: 88 with NT, 60 tic-free healthy controls (HC), and 39 with chronic tic disorder/Tourette syndrome (TS), using T1-weighted MRI and total tic scores (TTS) from the Yale Global Tic Severity Scale to evaluate symptom change. Subcortical surface maps were generated using FreeSurfer-initialized large deformation diffeomorphic metric mapping. Linear regression models correlated baseline structural shapes with follow-up TTS while accounting for covariates, with relationships mapped onto structure surfaces.
resultsWe found that the NT group had a larger right hippocampus compared to HC. Surface maps illustrate distinct patterns of inward deformation in the putamen and outward deformation in the thalamus for NT compared to controls. We also found patterns of outward deformation in almost all studied structures when comparing the TS group to controls. The NT group also showed consistent outward deformation compared to TS in the caudate, accumbens, putamen, and thalamus. Subsequent analyses including clinical symptoms revealed that a larger pallidum and thalamus at baseline correlated with less improvement of tic symptoms at follow-up.
conclusionThese observations constitute some of the first prognostic biomarkers for tic disorders and suggest that these subregional shape and volume differences may be associated with the outcome of tic disorders.
Indexed as
BrainTic DisordersTourette SyndromeAdolescentChildFemaleHumansMagnetic Resonance ImagingMaleThalamusFreeSurferneuroanatomyneurodevelopmental disordersstructural MRIsubcortical shapeTic disorderstourette syndrome
Identifiers
PMID39604269
PMCPMC11839322
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