Evidence map›Paper›PMID 39604167›Full record

ArticleJournal of the American Society for Mass Spectrometry2025

Infrared Photoactivation Enables nano-DESI MS of Protein Complexes in Tissue on a Linear Ion Trap Mass Spectrometer.

Oliver J Hale, Todd H Mize, Helen J Cooper

Abstract read
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Oliver J HaleSchool of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.ORCID 0000-0002-2286-5780
Todd H MizeSchool of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
Helen J CooperSchool of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.ORCID 0000-0003-4590-9384

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Native mass spectrometry analysis of proteins directly from tissues can be performed by using nanospray-desorption electrospray ionization (nano-DESI). Typically, supplementary collisional activation is essential to decluster protein complex ions from solvent, salt, detergent, and lipid clusters that comprise the ion beam. As an alternative, we have implemented declustering by infrared (IR) photoactivation on a linear ion trap mass spectrometer equipped with a CO

Indexed as

Infrared RaysSpectrometry, Mass, Electrospray IonizationAnimalsBrain ChemistryHumansLens, CrystallineNanotechnologyProteinsProteins

Identifiers

PMID39604167
PMCPMC11697349

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.