Evidence map›Paper›PMID 39604117›Full record

ArticleAging cell2025

The Ercc1

Akilavalli Narasimhan, Seok Hong Min, Laura L Johnson, Heidi Roehrich, William Cho, Tracy K Her, Caeden Windschitl, Ryan D O'Kelly, Luise Angelini, Matthew J Yousefzadeh and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Lack of Pnpla2 Accelerates Progression of AMD-Like Features in Mice.Investigative ophthalmology & visual science · 2025
    Article
  7. Review
  8. The Ercc1Aging cell · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Akilavalli NarasimhanInstitute on the Biology of Aging and Metabolism, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Seok Hong MinDepartment of Ophthalmology, University of Florida, Gainesville, Florida, USA.
Laura L JohnsonDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, USA.
Heidi RoehrichDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, USA.
William ChoDepartment of Physiology and Biophysics, Department of Ophthalmology, Center for Translational Vision Research, University of California Irvine, School of Medicine, Irvine, California, USA.
Tracy K HerDepartment of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota, USA.
Caeden WindschitlInstitute on the Biology of Aging and Metabolism, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Ryan D O'KellyInstitute on the Biology of Aging and Metabolism, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Luise AngeliniInstitute on the Biology of Aging and Metabolism, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Matthew J YousefzadehInstitute on the Biology of Aging and Metabolism, University of Minnesota Medical School, Minneapolis, Minnesota, USA.ORCID 0000-0003-2869-1029
Linda K McLoonDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, USA.
William W HauswirthDepartment of Ophthalmology, University of Florida, Gainesville, Florida, USA.
Paul D RobbinsInstitute on the Biology of Aging and Metabolism, University of Minnesota Medical School, Minneapolis, Minnesota, USA.ORCID 0000-0003-1068-7099
Dorota Skowronska-KrawczykDepartment of Physiology and Biophysics, Department of Ophthalmology, Center for Translational Vision Research, University of California Irvine, School of Medicine, Irvine, California, USA.ORCID 0000-0002-5758-4225
Laura J NiedernhoferInstitute on the Biology of Aging and Metabolism, University of Minnesota Medical School, Minneapolis, Minnesota, USA.ORCID 0000-0002-1074-1385

Funding

Validation and characterization of the identified variants associated with human longevity in mouse modelsU19AG056278 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JAN VIJG · 2017 to 2026
$24.5M
Midwest Murine-Tissue Mapping Center (MM-TMC)U54AG079754 · NIA · UNIVERSITY OF MINNESOTA · PI GR Scott Budinger, Sundeep Khosla · 2022 to 2026
$11.5M
TRAINING PROGRAM IN MUSCLE RESEARCHT32AR007612 · NIAMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI JAMES M ERVASTI, DAWN A LOWE · 2001 to 2026
$11.3M
NEI UCI Center Core Grant for Vision ResearchP30EY034070 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Rachel Wagner Martin · 2022 to 2026
$3.7M
Using the senolytic fisetin to suppress mortality in aged mice acutely exposed to murine beta-coronavirusR01AG063543 · NIA · UNIVERSITY OF MINNESOTA · PI NIEDERNHOFER, LAURA JANE · 2019 to 2023
$3.4M
Correlating Genomic AMD Risk Variants with Lipid Composition and Phagocytic Function of Patient-Derived Induced Pluripotent Stem Cell (iPSC)-derived Retinal Pigment Epithelium (RPE)U01EY034594 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI SKOWRONSKA-KRAWCZYK, DOROTA, WAHLIN, KARL J · 2022 to 2025
$1.6M
Common Fund P30EY034070Common Fund R01AG063543Common Fund U01EY034594Common Fund U19AG056278Common Fund U54AG079754NEI NIH HHS P30 EY034070NEI NIH HHS U01 EY034594NIAMS NIH HHS T32 AR007612NIA NIH HHS R01 AG063543NIA NIH HHS U19 AG056278NIA NIH HHS U54 AG079754
6 · The paper itself

Abstract

Age-related macular degeneration (AMD) is a major cause of vision loss in older adults. AMD is caused by degeneration in the macula of the retina. The retina is the highest oxygen consuming tissue in our body and is prone to oxidative damage. DNA damage is one hallmark of aging implicated in loss of organ function. Genome instability has been associated with several disorders that result in premature vision loss. We hypothesized that endogenous DNA damage plays a causal role in age-related retinal changes. To address this, we used a genetic model of systemic depletion of expression of the DNA repair enzyme ERCC1-XPF. The neural retina and retinal pigment epithelium (RPE) from Ercc1

Indexed as

DNA-Binding ProteinsEndonucleasesProgeriaRetinal DegenerationAnimalsDisease Models, AnimalDNA DamageHumansMacular DegenerationMiceRetinaRetinal Pigment EpitheliumDNA-Binding ProteinsEndonucleasesErcc1 protein, mouseage‐related retinal degenerationcellular senescenceDNA damage

Identifiers

PMID39604117
PMCPMC11896507

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.