ArticleActa paediatrica (Oslo, Norway : 1992)2025
Indocyanine green clearance's association with liver function in paediatric liver disease.
Article in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Dynamic Liver Function Tests in Paediatric Liver Disease.Diagnostics (Basel, Switzerland) · 2026Article
- Indocyanine Green Fluorescence Navigation in Pediatric Hepatobiliary Surgery: Systematic Review.Children (Basel, Switzerland) · 2025Review
- Indocyanine green clearance's association with liver function in paediatric liver disease.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
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Authors and funding
11 authors.
Funding
Abstract
aimIndocyanine green (ICG) clearance, a sensitive biomarker for liver function, has not been validated in children. We assessed the association between ICG clearance and liver function in children with liver disease.
methodsICG plasma disappearance rate (ICG-PDR, %/min) was measured in children with liver disease. Mixed linear regression was used to assess the relationship between ICG-PDR and liver function tests (international normalised ratio, INR; prothrombin-proconvertin clotting time, PP).
resultsWe included 124 patients with 183 visits. Of the visits, 60.1% were female, 85% had chronic liver disease and 42.5% were liver transplanted. The most common diseases in those without transplantation were autoimmune disease (18.6%) and biliary atresia (10.9%). Median ICG-PDR was 23.9%/min (interquartile range 15; 30.3). Mixed linear regression showed ICG-PDR was associated with INR (β = -0.006, 95% CI [-0.010, -0.003]) and PP (β = 0.005, 95% CI [0.003, 0.008]). However, only five visits were with patients who had acute liver failure (INR ≥2.0).
conclusionICG clearance is associated with standard measures of liver function in children. ICG may aid decision-making in paediatric liver disease together with other biochemical measures, imaging and clinical presentation. However, further studies are needed to assess the usefulness of ICG in paediatric patients with INR >1.4.
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