Evidence map›Paper›PMID 39604053›Full record

ArticleBritish journal of haematology2025

Inequalities in geographic barriers and patient representation in lymphoma clinical trials across England.

David A Jones, Katie Spencer, Johanna Ramroth, Jake Probert, Laurence S J Roope, Rebecca Shakir, John Broggio, Frank Burroughs, Graham P Collins, Philip M Clarke and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of haematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

David A JonesNuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-8440-1439
Katie SpencerLeeds Institute of Health Sciences, University of Leeds, Leeds, UK.
Johanna RamrothNuffield Department of Population Health, University of Oxford, Oxford, UK.
Jake ProbertNuffield Department of Population Health, University of Oxford, Oxford, UK.
Laurence S J RoopeNuffield Department of Population Health, University of Oxford, Oxford, UK.
Rebecca ShakirNuffield Department of Population Health, University of Oxford, Oxford, UK.
John BroggioNational Disease Registration Service, NHS England, Birmingham, UK.
Frank BurroughsBristol, UK.
Graham P CollinsOxford Cancer and Haematology Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Philip M ClarkeNuffield Department of Population Health, University of Oxford, Oxford, UK.
Jane L WolstenholmeNuffield Department of Population Health, University of Oxford, Oxford, UK.
David J CutterNuffield Department of Population Health, University of Oxford, Oxford, UK.

Funding

Cancer Research UK C8225/A21133Cancer Research UK PRCRPG-Nov21/100001National Institute for Health and Care Research NIHR300740NIHR Oxford Biomedical Research Centre
6 · The paper itself

Abstract

The distribution of trial site locations may lead to disparities in geographic access and affect patient representativeness in clinical trials. We utilised trial data covering 1993-2022 from the National Institute for Health and Care Research (NIHR) Open Data Platform, 2011 and 2021 English Census and geographic data and English individual-patient cancer registry data for patients diagnosed with lymphoma between 1997 and 2017. To assess representation, we compared patient age and sex between trial participants and the incident population. We mapped the distance and travel times of English lower layer super output areas (LSOAs) to their nearest research active NHS Trusts and assessed associations between distance and travel times and the geographic and sociodemographic characteristics of the LSOAs. Trial participants were younger than the incident population and more likely to be male. The closest NHS Trust to more than half of English LSOAs was not research active. Greater LSOA mean age, male percent, White British percent, rurality and coastal/border status were positively associated with distance and travel time (at prespecified p < 0.05 level), while greater deprivation was negatively associated. Female and older lymphoma patients in England are underrepresented in trials, with the latter facing a higher burden of geographic barriers.

Indexed as

Clinical Trials as TopicHealthcare DisparitiesLymphomaPatient SelectionAdultAgedAged, 80 and overEnglandFemaleHealth Services AccessibilityHumansMaleMiddle AgedSocioeconomic Factorsclinical trialsepidemiologylymphomas

Identifiers

PMID39604053
PMCPMC11829142

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.