ArticleNeurobiology of aging2025
Cerebral white matter hyperintensity volumes: Normative age- and sex-specific values from 15 population-based cohorts comprising 14,876 individuals.
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Article in Neurobiology of aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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19citing papers in PubMed, 1 pooled it
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exploring the impact of aging on motor imagery abilities: a systematic review with meta-analysis.Frontiers in public health · 2024Pooled it
- A phase-II randomized controlled pilot study of nicotinamide riboside supplementation in older adults with amnestic mild cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Trial
- Cardiac Biomarkers, Subclinical Brain Vascular Changes, and Cognitive Decline: Post Hoc Analysis of the SPRINT Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Trial
- Norms for Automatic Estimation of White Matter Hyperintensities Burden: LST-AI Service in neuGRID.Diagnostics (Basel, Switzerland) · 2026Article
- Age at Menopause and Brain Atrophy Among Older Women.JAMA network open · 2026Article
- The vascular contribution to dementia: World Stroke Organization scientific statement.International journal of stroke : official journal of the International Stroke Society · 2026Review
- The influence of blood lipids on cerebral perfusion by apolipoprotein E status.Journal of lipid research · 2026Article
- Association of coronary artery calcium and carotid intima-media thickness with white matter hyperintensity.Medicine · 2026Article
- Global burden of cerebral small vessel disease determined from large MRI studies: A systematic review and meta-analysis.International journal of stroke : official journal of the International Stroke Society · 2026Review
- Neuroimaging Biomarkers of Disease Progression and Cognitive Change in Patients With Retinal Vasculopathy With Cerebral Leukoencephalopathy.Neurology · 2026Article
- Effects of aerobic exercise intervention on the association between brain functional connectivity and cognition among older adults.Aging brain · 2026Article
- Transcranial doppler detected right-to-left shunt is common but not associated with MRI white matter hyperintensity burden: a cross-sectional study.European stroke journal · 2026Article
- Frequency of Microvascular Pathology and Hippocampal Atrophy on Magnetic Resonance Imaging in a Community Study of Alzheimer's Disease with Blood-Based Biomarkers.Annals of neurology · 2025Article
- The impact of occupational nonhypoxic hypobaria on cerebral function and integrity.Scientific reports · 2025Observational
- Associations between cerebral small vessel disease and reduced forced vital capacity and expiratory volume in a general healthy Swedish elder population study-Good Aging in Skåne.Journal of Alzheimer's disease : JAD · 2025Article
- Sensitivity of diffusion tensor imaging to regional mixed cerebrovascular pathology.Brain communications · 2025Article
- Changes in arterial flow velocity and pulsatility following endarterectomy for symptomatic high degree carotid artery stenosis: insights from the Carotis7T Study.Cerebral circulation - cognition and behavior · 2025Article
- White matter hyperintensities in Alzheimer's disease in the era of anti-amyloid therapies.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- White matter hyperintensities mediate a greater proportion of age-related lower cognitive scores in non-Hispanic White participants compared to non-Hispanic Black and Hispanic participants: HABS-HD.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
40 authors.
Floor A S de KortDepartment of Neurology, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands. Electronic address: f.a.s.dekort-3@umcutrecht.nl.
Elisabeth J VinkeDepartment of Radiology & Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Ewoud J van der LelijDepartment of Neurology, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands.
Devasuda AnblaganCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Mark E BastinCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Alexa BeiserDepartment of Biostatistics, Boston University, Boston, USA.
Henry BrodatyCentre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, UNSW Sydney, Sydney, Australia.
Nishi ChaturvediMRC Unit for Lifelong Health and Ageing, University College London, London, UK.
Bastian ChengDepartment of Neurology, University Medical Hospital Hamburg-Eppendorf, Hamburg, Germany.
Simon R CoxLothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Charles DeCarliDepartment of Neurology, University of California Davis, Sacramento, USA.
Christian EnzingerDepartment of Neurology, Medical University Graz, Graz, Austria.
Evan FletcherDepartment of Neurology, University of California Davis, Sacramento, USA.
Richard FrayneDepartment of Clinical Neurosciences, University of Calgary, Calgary, Canada; Department of Radiology, University of Calgary, Calgary, Canada.
Marius de GrootDepartment of Radiology & Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Felicia HuangMRC Unit for Lifelong Health and Ageing, University College London, London, UK.
M Arfan IkramDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Jiyang JiangCentre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, UNSW Sydney, Sydney, Australia.
Bonnie Y K LamDivision of Neurology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, China.
Pauline MaillardDepartment of Neurology, University of California Davis, Sacramento, USA.
Carola MayerDepartment of Neurology, University Medical Hospital Hamburg-Eppendorf, Hamburg, Germany.
Cheryl R McCrearyDepartment of Clinical Neurosciences, University of Calgary, Calgary, Canada; Department of Radiology, University of Calgary, Calgary, Canada.
Vincent MokDivision of Neurology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, China.
Susana Muñoz ManiegaCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Marvin PetersenDepartment of Neurology, University Medical Hospital Hamburg-Eppendorf, Hamburg, Germany.
Genady RoshchupkinDepartment of Radiology & Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Perminder S SachdevCentre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, UNSW Sydney, Sydney, Australia.
Reinhold SchmidtDepartment of Neurology, Medical University Graz, Graz, Austria.
Stephan SeilerDepartment of Neurology, Medical University Graz, Graz, Austria.
Sudha SeshadriGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, USA.
Carole H SudreMRC Unit for Lifelong Health and Ageing, University College London, London, UK; Centre for Medical Image Computing, University College London, London, UK; School of Biomedical Engineering & Imaging Sciences, King's College London, UK.
Götz ThomallaDepartment of Neurology, University Medical Hospital Hamburg-Eppendorf, Hamburg, Germany.
Raphael TwerenboldDepartment of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; DZHK (German Centre for Cardiovascular Research) partner site, Hamburg, Germany.
Maria Valdés HernándezCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Meike W VernooijDepartment of Radiology & Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Joanna M WardlawCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.
Wei WenCentre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, UNSW Sydney, Sydney, Australia.
Hugo J KuijfImage Sciences Institute, University Medical Center Utrecht, Utrecht, the Netherlands.
Geert Jan BiesselsDepartment of Neurology, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands.
J Matthijs BiesbroekDepartment of Neurology, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands; Department of Neurology, Diakonessenhuis Hospital, Utrecht, the Netherlands.
Funding
The Clinical Significance of Incidental White Matter Lesions on MRI Amongst a Diverse Population with Cognitive Complaints (INDEED)U19NS120384 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Charles DeCarli · 2020 to 2026
$61.9MFRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN · 2019 to 2024
$29.8MUC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3MUC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Charles DeCarli, Rachel A Whitmer · 2021 to 2026
$25.2MMRI, Genetics &Cognitive Precursors of AD &DementiaR01AG016495 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA · 1999 to 2016
$12.5MTemporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham CohortsR01AG054076 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DECARLI, CHARLES, SESHADRI, SUDHA · 2016 to 2020
$12.3MMRI, Cognitive, Genetic & Biomarker Precursors of AD & Dementia in Young AdultsR01AG033040 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 2009 to 2019
$11.2MBrain pathologies, reserve and cognition in aging and dementiaR01AG031563 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Evan Fletcher, SARAH E TOMASZEWSKI-FARIAS · 2009 to 2026
$8.9MNovel Imaging and Biofluid Biomarkers of Small Vessel Cerebrovascular DiseaseUF1NS100608 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRAMER, JOEL H · 2021 to 2021
$2.5MMedical Research Council G0701120Medical Research Council G1001245NHLBI NIH HHS 75N92019D00031NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG072972NIA NIH HHS R01 AG016495NIA NIH HHS R01 AG031563NIA NIH HHS R01 AG033040NIA NIH HHS R01 AG054076NINDS NIH HHS U19 NS120384NINDS NIH HHS UF1 NS100608Wellcome Trust
Abstract
White matter hyperintensities (WMH) increase with age, with marked interindividual variation. There is a need for normative data by age and sex, to improve individualized WMH burden assessment. In this study, we pooled cross-sectional data from 15 population-based cohorts (14,876 nondemented individuals, age 18-97 years), through the Meta VCI Map consortium. Whole brain and tract-specific MRI-assessed WMH volumes were calculated in MNI-152 space. We used quantile regression to create centile curves of WMH volume versus age, stratified by sex. Total WMH volume and interindividual variance increased exponentially with age for both sexes, with females showing higher WMH volumes. WMH volume increase with aging was not uniform across the white matter, but instead followed one of three different patterns depending on location. Age- and sex-specific normative data for total and regional WMH volumes were created. Our study provides detailed information on the normal distribution of total and regional WMH volumes across adulthood. The normative data enable a quantitative approach to interpreting total and regional WMH volumes in clinical practice and research settings.
Indexed as
AgingMagnetic Resonance ImagingSex CharacteristicsWhite MatterAdolescentAdultAgedAged, 80 and overCohort StudiesCross-Sectional StudiesFemaleHumansMaleMiddle AgedOrgan SizeYoung AdultAgingCerebral small vessel diseaseMRINormative dataPopulation-basedWhite matter hyperintensities
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