Evidence map›Paper›PMID 39602819›Full record

ArticleThe Journal of infectious diseases2025

Asymptomatic and Mildly Symptomatic Influenza Virus Infections by Season: Case-Ascertained Household Transmission Studies, United States, 2017-2023.

Jessica E Biddle, Huong Q Nguyen, H Keipp Talbot, Melissa A Rolfes, Matthew Biggerstaff, Sheroi Johnson, Carrie Reed, Edward A Belongia, Carlos G Grijalva, Alexandra M Mellis

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Detection of SARS-CoV-2 RNA on air purifier filters in university spaces without symptomatic or confirmed cases.Aerosol science and technology : the journal of the American Association for Aerosol Research · 2025
    Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Jessica E BiddleInfluenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID 0000-0001-6702-8698
Huong Q NguyenMarshfield Clinic Research Institute, Marshfield, Wisconsin, USA.ORCID 0000-0003-2725-6439
H Keipp TalbotVanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-0141-1760
Melissa A RolfesInfluenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Matthew BiggerstaffInfluenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Sheroi JohnsonInfluenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID 0000-0002-4045-9209
Carrie ReedInfluenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID 0000-0001-7944-7638
Edward A BelongiaMarshfield Clinic Research Institute, Marshfield, Wisconsin, USA.
Carlos G GrijalvaVanderbilt University Medical Center, Nashville, Tennessee, USA.
Alexandra M MellisInfluenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
CDC; 5U01IP001078CDC; 5U01IP001083CDC HHSCDC HHS 75D30121C11656NCATS NIH HHS 5UL1TR002243-03NCATS NIH HHS UL1 TR002243NCIRD CDC HHS U01 IP001078NCIRD CDC HHS U01 IP001083
6 · The paper itself

Abstract

Asymptomatic influenza virus infection occurs but may vary by factors such as age, vaccination status, or season. We examined the frequency of influenza virus infection and symptoms using data from 2 case-ascertained household transmission studies (2017-2023) with prospective, systematic collection of respiratory specimens and symptoms. From the 426 influenza virus infected household contacts that met our inclusion criteria, 8% were asymptomatic, 6% had nonrespiratory symptoms, 23% had acute respiratory symptoms, and 62% had influenza-like illness symptoms. Understanding the prevalence of asymptomatic and mildly symptomatic influenza cases is important for implementing effective influenza prevention strategies and enhancing symptom-based surveillance systems.

Indexed as

Asymptomatic InfectionsInfluenza, HumanAdolescentAdultAgedChildChild, PreschoolFamily CharacteristicsFemaleHumansInfantMaleMiddle AgedPrevalenceProspective StudiesSeasonsacute respiratory illnessasymptomaticcase-ascertainedhousehold transmissioninfluenzainfluenza-like illness

Identifiers

PMID39602819
PMCPMC13381266

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.