Observational studyThe Journal of clinical endocrinology and metabolism2025
Skeletal Effects of Sleeve Gastrectomy, by Sex and Menopausal Status and Compared to Roux-En-Y Gastric Bypass Surgery.
Observational study in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Why Do We Lose Bone During Weight Loss: Can It Be Prevented?Current osteoporosis reports · 2026Review
- Deciphering inter-organ communication: The multi-organ-bone axis in osteoporosis and emerging therapeutic strategies.Journal of orthopaedic translation · 2026Review
- Impact of Menopausal Status and Female Reproductive Aging on the Outcomes of Bariatric Surgery: A Narrative Review.Cureus · 2026Review
- Weight loss induced bone loss: mechanism of action and clinical implications.Bone research · 2025Review
- Are we giving too much weight to lean mass loss?Molecular metabolism · 2025Review
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16 authors.
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Abstract
contextRoux-en-Y gastric bypass (RYGB) has deleterious effects on bone mass, microarchitecture, and strength. The skeletal effects of sleeve gastrectomy (SG), now the most commonly performed bariatric surgical procedure, are incompletely understood.
objectiveWe examined changes in bone turnover, areal bone mineral density (aBMD) and volumetric bone mineral density (vBMD), and appendicular bone microarchitecture and estimated strength after SG. We compared the results to those previously reported after RYGB, hypothesizing lesser effects after SG than RYGB. DESIGN, SETTING,
participantsProspective observational cohort study of 54 adults with obesity undergoing SG at an academic center.
main outcome measuresSkeletal characterization with biochemical markers of bone turnover, dual-energy X-ray absorptiometry, quantitative computed tomography, and high-resolution peripheral QCT was performed preoperatively and 6 and 12 months postoperatively.
resultsOver 12 months, the mean percentage weight loss was 28.8%. Bone turnover marker levels increased, and total hip aBMD decreased -8.0% (95% CI -9.1%, -6.7%, P < 0.01). Spinal aBMD and vBMD declines were larger in postmenopausal women than men. Tibial and radial trabecular and cortical microstructure worsened, as did tibial estimated strength, particularly in postmenopausal women. When compared to data from a RYGB cohort with identical design and measurements, some SG biochemical, vBMD, and radial microstructural changes were smaller, while other changes were not.
conclusionBone mass, microstructure, and strength decrease after SG. Some skeletal parameters change less after SG than after RYGB, while for others we find no evidence for smaller effects after SG. Postmenopausal women may be at the highest risk of skeletal consequences after SG.
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