Evidence map›Paper›PMID 39602538›Full record

ArticleScience advances2024

The antiviral JNJ-A07 significantly reduces dengue virus transmission by

Ana L Rosales-Rosas, Sara Goossens, Winston Chiu, Atreyee Majumder, Alina Soto, Serge Masyn, Bart Stoops, Lanjiao Wang, Suzanne J F Kaptein, Olivia Goethals and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ana L Rosales-RosasKU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Virus-Host Interactions & Therapeutic Approaches (VITA) Research Group, 3000 Leuven, Belgium.ORCID 0000-0002-2099-9152
Sara GoossensKU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Virus-Host Interactions & Therapeutic Approaches (VITA) Research Group, 3000 Leuven, Belgium.
Winston ChiuKU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Virology, Antiviral Drug & Vaccine Research Group, 3000 Leuven, Belgium.ORCID 0000-0001-5236-623X
Atreyee MajumderJanssen R&D, Titusville, NJ, USA.ORCID 0000-0002-8185-5785
Alina SotoKU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Virus-Host Interactions & Therapeutic Approaches (VITA) Research Group, 3000 Leuven, Belgium.ORCID 0000-0002-3601-7424
Serge MasynJanssen Global Public Health, Janssen Pharmaceutica NV, Beerse, Belgium.ORCID 0000-0002-4296-1809
Bart StoopsJanssen R&D, Beerse, Belgium.ORCID 0000-0002-1092-2696
Lanjiao WangKU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Virus-Host Interactions & Therapeutic Approaches (VITA) Research Group, 3000 Leuven, Belgium.ORCID 0000-0002-5699-1443
Suzanne J F KapteinKU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Virology, Antiviral Drug & Vaccine Research Group, 3000 Leuven, Belgium.ORCID 0000-0002-7935-0219
Olivia GoethalsJanssen Global Public Health, Janssen Pharmaceutica NV, Beerse, Belgium.ORCID 0000-0001-8214-8989
Leen DelangKU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Virus-Host Interactions & Therapeutic Approaches (VITA) Research Group, 3000 Leuven, Belgium.ORCID 0000-0002-8874-675X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dengue virus (DENV) is the most widespread mosquito-borne virus worldwide, but no antiviral therapies are available yet. The pan-serotype DENV inhibitor JNJ-A07 has shown potent activity in a mouse model. It remains unknown whether an antiviral drug ingested by mosquitoes could inhibit virus replication and thus reduce transmission to other hosts. Here, we investigated the antiviral activity of JNJ-A07 when administered in the blood meal to

Indexed as

AedesAntiviral AgentsDengueDengue VirusAminophenolsAnimalsButyratesFeeding BehaviorFemaleHumansIndolesMiceMosquito VectorsVirus Replication(+)-4-(3-((1-(4-chlorophenyl)-2-oxo2-(6-(trifluoromethoxy)indolin-1-yl)ethyl)amino)-5-methoxyphenoxy)butanoic acidAminophenolsAntiviral AgentsButyratesIndoles

Identifiers

PMID39602538
PMCPMC11601208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.