SynthesisScience advances2024
Cesarean delivery and blood DNA methylation at birth and childhood: Meta-analysis in the Pregnancy and Childhood Epigenetics Consortium.
Abstract readMeta-Analysis
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Synthesis in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4citing papers in PubMed
–field-weighted citation impact
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Who cites it
4 citing papers in PubMed.
- From signals to systems: the epigenetic-microbiome-mitochondrial axis in IBD pathogenesis.Gut microbes · 2026Review
- Promotion of long-term health in early life.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The Impact of Nutrition on DNA Methylation: Methodological Challenges in Understanding Cause and Effect.Nutrients · 2026Review
- Impact of a prenatal exposure mixture of metals on DNA methylation-derived cell-type composition in cord blood.Environmental epigenetics · 2026Article
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Authors and funding
57 authors.
Siwen WangDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA.ORCID 0000-0002-5605-2016
Emma CaseyDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.ORCID 0009-0006-8333-5237
Joanne SordilloDivision of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA.
Sofía Aguilar-LacasañaISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona 08003, Spain.ORCID 0000-0002-7953-1589
Fernanda Morales BersteinMRC Integrative Epidemiology Unit at the University of Bristol, Bristol BS8 2BN, UK.ORCID 0000-0002-8237-2021
Richard J BiedrzyckiGlotech Inc., contractor for Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20850, USA.ORCID 0000-0003-1994-2295
Sonia BrescianiniCenter for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Rome 00161 Italy.ORCID 0000-0003-2627-1282
Su ChenDepartment of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, NE 68105, USA.
Amy HoughBradford Institute for Health Research, Bradford BD9 6RJ, UK.ORCID 0000-0001-5212-1857
Elena IsaevskaCancer Epidemiology Unit, Department of Medical Sciences, University of Turin, Turin 10126, Italy.ORCID 0000-0002-1846-7990
Woo Jin KimDepartment of Internal Medicine, Kangwon National University, Chuncheon 24289, Korea.ORCID 0000-0003-2927-370X
Marion LecorguilléUniversité Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Center for Research in Epidemiology and StatisticS (CRESS), F-75004 Paris, France.ORCID 0000-0002-6915-533X
Sebastian Shaobo LiCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA 90033, USA.ORCID 0000-0002-0544-5338
Christian M PageCentre for Fertility and Health, Norwegian Institute of Public Health, P.O. box 222 Skøyen, 0213 Oslo, Norway.ORCID 0000-0002-1897-3666
Jaehyun ParkInterdisciplinary Program of Bioinformatics, College of Natural Sciences, Seoul National University, Seoul 08826, Korea.ORCID 0000-0003-2900-8340
Stefan RöderDepartment of Environmental Immunology, Helmholtz Centre for Environmental Research - UFZ, Leipzig 04318, Germany.ORCID 0000-0001-9367-663X
Kristina SalontajiDepartment of Child and Adolescent Psychiatry / Psychology, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3015 GD, Netherlands.ORCID 0009-0008-4706-1106
Gillian SantorelliBradford Institute for Health Research, Bradford BD9 6RJ, UK.
Yidan SunUniversity of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Department of Pediatric Pulmonology and Pediatric Allergology, Groningen 9700 RB, Netherlands.
Sungho WonInterdisciplinary Program of Bioinformatics, College of Natural Sciences, Seoul National University, Seoul 08826, Korea.ORCID 0000-0001-5751-5089
Eric ZillichDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim 68159, Germany.
Lea ZillichDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim 68159, Germany.
Isabella Annesi-MaesanoDesbrest Institute of Epidemiology and Public Health, Univ Montpellier, INSERM, Montpellier, France.
S Hasan ArshadClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.
Mariona BustamanteISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona 08003, Spain.ORCID 0000-0003-0127-2860
Charlotte A M CecilDepartment of Child and Adolescent Psychiatry / Psychology, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3015 GD, Netherlands.ORCID 0000-0002-2389-5922
Hannah R ElliottMRC Integrative Epidemiology Unit at the University of Bristol, Bristol BS8 2BN, UK.ORCID 0000-0002-1500-3533
Susan EwartCollege of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA.
Janine F FelixThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3015 GD, Netherlands.ORCID 0000-0002-9801-5774
Luigi GagliardiDepartment of Mother and Child Health, Azienda USL Toscana Nord Ovest, Pisa 56121, Italy.ORCID 0000-0001-6074-8975
Siri E HåbergCentre for Fertility and Health, Norwegian Institute of Public Health, P.O. box 222 Skøyen, 0213 Oslo, Norway.
Gunda HerberthDepartment of Environmental Immunology, Helmholtz Centre for Environmental Research - UFZ, Leipzig 04318, Germany.ORCID 0000-0003-0212-3509
Barbara HeudeUniversité Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Center for Research in Epidemiology and StatisticS (CRESS), F-75004 Paris, France.ORCID 0000-0002-1565-1629
John W HollowayHuman Development and Health, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.ORCID 0000-0001-9998-0464
Anke HuelsDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0002-6005-417X
Wilfried KarmausDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN 38152, USA.
Gerard H KoppelmanUniversity of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Department of Pediatric Pulmonology and Pediatric Allergology, Groningen 9700 RB, Netherlands.ORCID 0000-0001-8567-3252
Stephanie J LondonNational Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.ORCID 0000-0003-4911-5290
Sunni L MumfordDepartment of Biostatistics, Epidemiology and Informatics and Department of Obstetrics and Gynecology, Perelman School of Medicine, Philadelphia, PA 19087, USA.ORCID 0000-0003-0133-3176
Lorenza NisticòCenter for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Rome 00161 Italy.ORCID 0000-0003-1805-6240
Maja PopovicCancer Epidemiology Unit, Department of Medical Sciences, University of Turin, Turin 10126, Italy.ORCID 0000-0003-4500-6572
Franca RusconiDepartment of Mother and Child Health, Azienda USL Toscana Nord Ovest, Pisa 56121, Italy.ORCID 0000-0002-9544-6472
Enrique F SchistermanDepartment of Biostatistics, Epidemiology and Informatics and Department of Obstetrics and Gynecology, Perelman School of Medicine, Philadelphia, PA 19087, USA.ORCID 0000-0003-3757-641X
Dan J SteinSouth African Medical Research Council (SAMRC) Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Rondebosch 7700, South Africa.ORCID 0000-0001-7218-7810
Tabea SendDepartment of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim 68159, Germany.
Henning TiemeierDepartment of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA.ORCID 0000-0002-4395-1397
Judith M VonkGroningen Research Institute for Asthma and COPD, Groningen 9700 RB, Netherlands.ORCID 0000-0001-7531-4547
Martine VrijheidISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona 08003, Spain.ORCID 0000-0002-7090-1758
Joseph Leo WiemelsCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA 90033, USA.
Stephanie H WittDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim 68159, Germany.ORCID 0000-0002-1571-1468
John WrightBradford Institute for Health Research, Bradford BD9 6RJ, UK.ORCID 0000-0001-9572-7293
Edwina H YeungEpidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20817 USA.
Heather J ZarSouth African Medical Research Council (SAMRC) Unit on Child and Adolescent Health, Department of Paediatrics, University of Cape Town, Rondebosch 7700, South Africa.ORCID 0000-0002-9046-759X
Ana C ZenclussenDepartment of Environmental Immunology, Helmholtz Centre for Environmental Research - UFZ, Leipzig 04318, Germany.ORCID 0000-0003-3544-4552
Hongmei ZhangDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN 38152, USA.ORCID 0000-0003-3557-0364
Jorge E ChavarroDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA.ORCID 0000-0002-4436-9630
Marie-France HivertDivision of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA.ORCID 0000-0001-7752-2585
Funding
Long-term health consequences of birth by cesarean sectionR01HD093761 · NICHD · HARVARD SCHOOL OF PUBLIC HEALTH · PI CHAVARRO, JORGE EDUARDO · 2018 to 2022
$3.3MNICHD NIH HHS R01 HD093761
Abstract
Children born via cesarean delivery have a higher risk of metabolic, immunological, and neurodevelopmental disorders compared to those born via vaginal delivery, although mechanisms remain unclear. We conducted a meta-analysis of epigenome-wide association studies to examine the associations between delivery mode and blood DNA methylation at birth and its persistence in early childhood. Participants were from 19 pregnancy cohorts (9833 term newborns) and 6 pediatric cohorts (2429 children aged 6 to 10 years). We identified six CpGs in cord blood associated with cesarean delivery (effect size range: 0.4 to 0.7%,
Indexed as
Cesarean SectionCpG IslandsDNA MethylationEpigenesis, GeneticChildFemaleFetal BloodGenome-Wide Association StudyHumansInfant, NewbornPregnancy
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