Evidence map›Paper›PMID 39602533›Full record

ArticleScience advances2024

TCF1 dosage determines cell fate during T cell development.

Anjali Verma, Bridget Aylward, Fei Ma, Cheryl A Sherman, Laura Chopp, Susan Shinton, Roshni Roy, Shawn Fahl, Alejandra Contreras, Byron Koenitzer and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Anjali VermaLaboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD, USA.ORCID 0009-0007-3039-1945
Bridget AylwardNuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia, PA, USA.ORCID 0000-0002-0377-2028
Fei MaLaboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD, USA.ORCID 0000-0003-0401-0954
Cheryl A ShermanLaboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD, USA.ORCID 0000-0001-7977-4698
Laura ChoppLaboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-6494-4439
Susan ShintonNuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia, PA, USA.ORCID 0000-0003-2649-1904
Roshni RoyLaboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD, USA.
Shawn FahlNuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia, PA, USA.ORCID 0000-0002-0489-2048
Alejandra ContrerasNuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia, PA, USA.ORCID 0000-0003-3653-5958
Byron KoenitzerLaboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD, USA.ORCID 0009-0004-1861-8711
Parirokh AwasthiMouse Modeling & Cryopreservation (MMC), The NCI Mouse Repository, Laboratory Animal Sciences Program, National Cancer Institute, Frederick, MD, USA.ORCID 0000-0002-5831-9781
Krystyna Mazan-MamczarzLaboratory of Genetics & Genomics, National Institute on Aging, Baltimore, MD, USA.ORCID 0009-0005-1545-0500
Supriyo DeLaboratory of Genetics & Genomics, National Institute on Aging, Baltimore, MD, USA.ORCID 0000-0002-2075-7655
Noah OllikainenLaboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD, USA.ORCID 0000-0002-1174-2400
Xiang QiuLaboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD, USA.ORCID 0000-0001-9161-9033
Remy BosselutLaboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-2033-1790
Ranjan SenLaboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD, USA.ORCID 0000-0002-1916-3905
David L WiestNuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia, PA, USA.ORCID 0000-0002-0792-3188
Jyoti Misra SenLaboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD, USA.ORCID 0000-0002-6365-0866

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Dietmar J Kappes · 1985 to 2026
$138.8M
The role of TCR, ligand, and signal strength in human γδ T cell developmentP01AI102853 · NIAID · RESEARCH INST OF FOX CHASE CAN CTR · PI Maria Ciofani · 2014 to 2026
$26.3M
NCI NIH HHS P30 CA006927NIAID NIH HHS P01 AI102853
6 · The paper itself

Abstract

Loss-of-function studies have shown that transcription factor T cell factor-1 (TCF1), encoded by the

Indexed as

Cell DifferentiationT Cell Transcription Factor 1T-LymphocytesAnimalsCell LineageEnhancer Elements, GeneticGene DosageHepatocyte Nuclear Factor 1-alphaMiceReceptors, Antigen, T-Cell, alpha-betaThymus GlandHepatocyte Nuclear Factor 1-alphaHnf1a protein, mouseReceptors, Antigen, T-Cell, alpha-betaT Cell Transcription Factor 1

Identifiers

PMID39602533
PMCPMC11601199

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.