ArticleScience translational medicine2024
Sexually dimorphic differences in angiogenesis markers are associated with brain aging trajectories in humans.
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Article in Science translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7citing papers in PubMed
–field-weighted citation impact
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Who cites it
7 citing papers in PubMed.
- Role of angiogenic signaling through placental growth factor in white matter injury and cognitive decline.Neural regeneration research · 2026Article
- On a Keller-Segel type equation to model Brain Microvascular Endothelial Cells growth's patterns.ArXiv · 2026Article
- Linking cross-species trajectories of cerebrovascular remodeling in aging and Alzheimer's disease to brain vessel transcriptome.bioRxiv : the preprint server for biology · 2026Article
- Spatially convergent functional MRI signatures of diabetes and male sex identify genetic vulnerabilities to accelerated brain ageing.Brain communications · 2026Article
- Health and aging trajectories: shared and competing risks and resiliencies for chronic diseases associated with aging. A NIH-wide workshop.Frontiers in public health · 2025Article
- Brain imaging data and summary data-based Mendelian randomization analysis reveal the impact of multiorgan aging on schizophrenia.Frontiers in psychiatry · 2025Article
- Using digital pathology to analyze the murine cerebrovasculature.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
Corrections and comments
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Authors and funding
17 authors.
Abel Torres-EspinSchool of Public Health Sciences, Faculty of Health, University of Waterloo, Waterloo, ON N2L 3G1, Canada.ORCID 0000-0002-9787-8738
Hannah L RadabaughDepartment of Neurological Surgery, Brain and Spinal Injury Center (BASIC), Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0001-9820-9862
Scott TreimanDepartment of Neurological Surgery, Brain and Spinal Injury Center (BASIC), Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0001-7833-376X
Stephen S FitzsimonsDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-1576-8632
Danielle HarveyDepartment of Public Health Sciences, University of California, Davis, Davis, CA 95616, USA.ORCID 0000-0002-5367-0951
Austin ChouDepartment of Neurological Surgery, Brain and Spinal Injury Center (BASIC), Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0003-4328-5811
Cutter A LindberghDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-9329-4663
Kaitlin B CasalettoDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Lauren GoldbergerDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Adam M StaffaroniDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Pauline MaillardDepartment of Neurology, University of California, Davis, Davis, CA 95817, USA.ORCID 0000-0003-3516-6345
Bruce L MillerDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-2152-4220
Charles DeCarliDepartment of Neurology, University of California, Davis, Davis, CA 95817, USA.ORCID 0000-0003-1914-2693
Jason D HinmanDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-0872-5044
Adam R FergusonDepartment of Neurological Surgery, Brain and Spinal Injury Center (BASIC), Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0001-7102-1608
Joel H KramerDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-2917-8297
Fanny M ElahiDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0003-4663-4992
Funding
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2MResearch Education ComponentP30AG066514 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Margaret Sewell · 2020 to 2026
$31.0MUC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI JOHNSON, DAVID K · 1991 to 2020
$28.3MPrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MILLER, BRUCE L · 2004 to 2018
$27.1MUC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Charles DeCarli, Rachel A Whitmer · 2021 to 2026
$25.2MTools for Common Data Element Adoption in the Pan-Neurotrauma Data Commons (PANORAUMA)U24NS122732 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ADAM R FERGUSON, Jeffrey S. Grethe · 2021 to 2026
$5.0MNovel imaging and endothelial biomarkers of small vessel cerebrovascular diseaseUH3NS100608 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DECARLI, CHARLES, KRAMER, JOEL H · 2018 to 2020
$3.5MNovel Imaging and Biofluid Biomarkers of Small Vessel Cerebrovascular DiseaseU01NS100608 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRAMER, JOEL H · 2023 to 2025
$3.2MMaladaptive Plasticity in Spinal Cord Injury: Cellular MechanismsR01NS122888 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERGUSON, ADAM R · 2021 to 2025
$3.0MNovel Imaging and Biofluid Biomarkers of Small Vessel Cerebrovascular DiseaseUF1NS100608 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRAMER, JOEL H · 2021 to 2021
$2.5MNovel imaging and endothelial biomarkers of small vessel cerebrovascular diseaseUH2NS100608 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DECARLI, CHARLES, KRAMER, JOEL H · 2016 to 2017
$2.1MTranslational Outcomes Project: Visualizing Syndromic Information and Outcomes for Neurotrauma (TOP-VISION)UH3NS106899 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BEATTIE, MICHAEL S, BRESNAHAN, JACQUELINE C · 2020 to 2022
$1.2MBLRD VA I01 BX005871BLRD VA I50 BX005878CSRD VA IK2 CX002180NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG066514NIA NIH HHS P30 AG072972NIA NIH HHS P50 AG023501NINDS NIH HHS R01 NS122888NINDS NIH HHS U01 NS100608NINDS NIH HHS U24 NS122732NINDS NIH HHS UF1 NS100608NINDS NIH HHS UH2 NS100608NINDS NIH HHS UH3 NS100608NINDS NIH HHS UH3 NS106899RRD VA I01 RX002245RRD VA I01 RX002787
Abstract
Aberrant angiogenesis could contribute to the development of cognitive impairment and represent a therapeutic target for preventing dementia. However, most studies addressing angiogenesis and cognitive impairment focus on model organisms. To test the relevance of angiogenesis to human cognitive aging, we evaluated associations of circulating blood markers of angiogenesis with brain aging trajectories in a pooled two-center sample from deeply phenotyped longitudinal human cohorts (
Indexed as
AgingBiomarkersBrainSex CharacteristicsAgedAged, 80 and overAngiogenesisFemaleHumansMaleNeovascularization, PhysiologicBiomarkers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.