Evidence map›Paper›PMID 39602264›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

CO

Aaron M Fleming, Justin C Dingman, Cynthia J Burrows

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. COProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

  • Update of
    CO2024
5 · Who and what money

Authors and funding

3 authors.

Aaron M FlemingDepartment of Chemistry, University of Utah, Salt Lake City, UT 84112-0850.ORCID 0000-0002-2000-0310
Justin C DingmanDepartment of Chemistry, University of Utah, Salt Lake City, UT 84112-0850.
Cynthia J BurrowsDepartment of Chemistry, University of Utah, Salt Lake City, UT 84112-0850.ORCID 0000-0001-7253-8529

Funding

Chemical Modifications in Regulatory Regions of DNA and RNAR35GM145237 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Cynthia J Burrows · 2022 to 2026
$2.3M
Agilent 6550 QTOF system for U of UtahS10OD016232 · OD · UNIVERSITY OF UTAH · PI COX, JAMES ERIC · 2013 to 2013
$578k
Q-ToF Mass Spectrometer for the University of Utah MS and Proteomics CoreS10OD018210 · OD · UNIVERSITY OF UTAH · PI COX, JAMES ERIC · 2015 to 2015
$530k
Agilent 7200 GC/Q-TOF for the University of UtahS10OD021505 · OD · UNIVERSITY OF UTAH · PI COX, JAMES ERIC · 2016 to 2016
$401k
Enhancing Oversight of Human Subjects ResearchS07RR018210 · NCRR · AMERICAN COLLEGE OF SURGEONS · PI RUSSELL, THOMAS R · 2002 to 2002
$63k
HHS | NIH | National Center for Research Resources (NCRR) 1S10OD016232HHS | NIH | National Center for Research Resources (NCRR) 1S10OD018210HHS | NIH | National Center for Research Resources (NCRR) 1S10OD021505NIGMS NIH HHS R35 GM145237NIH HHS S10 OD016232NIH HHS S10 OD018210NIH HHS S10 OD021505
6 · The paper itself

Abstract

While hydroxyl radical is commonly named as the Fenton product responsible for DNA and RNA damage in cells, here we demonstrate that the cellular reaction generates carbonate radical anion due to physiological bicarbonate levels. In human and

Indexed as

DNA DamageEscherichia coliHydrogen PeroxideIronOxidation-ReductionBicarbonatesCarbon DioxideGuanineHumansOxidative StressTranscriptomeBicarbonatesCarbon DioxideGuanineHydrogen PeroxideIronbicarbonateDNA repairDNA/RNA oxidationFenton reaction

Identifiers

PMID39602264
PMCPMC11626140

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.