Evidence map›Paper›PMID 39602259›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Constitutive opening of the Kv7.2 pore activation gate causes

Mario Nappi, Giulio Alberini, Alessandro Berselli, Agnese Roscioni, Maria Virginia Soldovieri, Ilenio Servettini, Vincenzo Barrese, Sarah Weckhuysen, Ting-Gee Annie Chiu, Ingrid E Scheffer and 4 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. NovelInternational journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mario Nappi *Department of Neuroscience, Section of Pharmacology, University of Naples Federico II, Naples 80131, Italy.ORCID 0000-0002-1243-0935
Giulio Alberini *Center for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Genova 16132, Italy.ORCID 0000-0003-2794-2084
Alessandro BerselliCenter for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Genova 16132, Italy.ORCID 0000-0002-2241-3530
Agnese RoscioniCenter for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Genova 16132, Italy.
Maria Virginia SoldovieriDepartment of Medicine and Health Science, University of Molise, Campobasso 86100, Italy.ORCID 0000-0002-3601-9374
Ilenio ServettiniDepartment of Medicine and Health Science, University of Molise, Campobasso 86100, Italy.ORCID 0000-0002-6163-7975
Vincenzo BarreseDepartment of Neuroscience, Section of Pharmacology, University of Naples Federico II, Naples 80131, Italy.ORCID 0000-0001-8721-8843
Sarah WeckhuysenApplied & Translational Neurogenomics Group, Vlaams Instituut voor Biotechnology (VIB) Center for Molecular Neurology, Antwerp 2610, Belgium.
Ting-Gee Annie ChiuDivision of Medicine, Dentistry and Health Sciences, University of Melbourne, Austin Health, Melbourne, VIC 3084, Australia.ORCID 0000-0003-0249-9725
Ingrid E SchefferThe Florey Institute of Neuroscience and Mental Health and Murdoch Children's Research Institutes, University of Melbourne, Austin and Royal Children's Hospital, Melbourne, VIC 3052, Australia.
Fabio BenfenatiCenter for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Genova 16132, Italy.ORCID 0000-0002-0653-8368
Luca MaraglianoCenter for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Genova 16132, Italy.
Francesco MiceliDepartment of Neuroscience, Section of Pharmacology, University of Naples Federico II, Naples 80131, Italy.ORCID 0000-0002-5393-1402
Maurizio TaglialatelaDepartment of Neuroscience, Section of Pharmacology, University of Naples Federico II, Naples 80131, Italy.ORCID 0000-0002-8202-0560

Funding

European Joint Programme on Rare Disease JTC 2020 TREATKCNQFonds Wetenschappelijk Onderzoek (FWO) 1861419 N G041821NMinistero della Salute (Italy Ministry of Health) PNRR-MR1-2022-12376528Ministero della Salute (Italy Ministry of Health) RF-2019-12370491Ministero dell'Istruzione, dell'Università e della Ricerca (MIUR) PRIN 2020XBFEMSMinistero dell'Università e della Ricerca (MUR) MNESYS ProjectMinistero dell'Università e della Ricerca (MUR) PRIN 2022M3KJ4NMinistero dell'Università e della Ricerca (MUR) PRIN P2022FJXY5Wellcome Trust
6 · The paper itself

Abstract

Pathogenic variants in

Indexed as

Ion Channel GatingKCNQ2 Potassium ChannelMolecular Dynamics SimulationAnimalsBrain DiseasesFemaleHumansKCNQ3 Potassium ChannelMaleMutationPhosphatidylinositol 4,5-DiphosphateKCNQ2 Potassium ChannelKCNQ2 protein, humanKCNQ3 Potassium ChannelKCNQ3 protein, humanPhosphatidylinositol 4,5-Diphosphatechannel gatingdevelopmental and epileptic encephalopathiesGenotype–phenotype correlationsMolecular dynamicspotassium channels

Identifiers

PMID39602259
PMCPMC11626135

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.