Evidence map›Paper›PMID 39602254›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

BCL2 regulates antibacterial autophagy in the intestinal epithelium.

Yun Li, Shai Bel, Jamaal L Benjamin, Kelly A Ruhn, Brian Hassell, Cassie L Behrendt, Zheng Kuang, Lora V Hooper

Erratum issuedAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Yun LiDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Shai BelDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-7166-4870
Jamaal L BenjaminDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Kelly A RuhnDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Brian HassellDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Cassie L BehrendtDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Zheng KuangDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Lora V HooperDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-2759-4641

Funding

Microbial Regulation of Retinol Transport and its Role in Intestinal ImmunityR01DK070855 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI LORA V HOOPER · 2005 to 2026
$7.9M
INTEGRATIVE IMMUNOLOGY TRAINING PROGRAMT32AI005284 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Nan Yan · 2003 to 2026
$7.4M
Behavioral quantification through active learning and multidimensional physiological monitoringR34DA059509 · NIDA · CARNEGIE-MELLON UNIVERSITY · PI GROVER, PULKIT, KUANG, ZHENG · 2024 to 2025
$663k
Microbiota-dependent Epigenetic Regulation of Circadian Rhythms in Nutrient Uptake and Energy HomeostasisK99DK120897 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI KUANG, ZHENG · 2019 to 2020
$182k
Gruss-Lipper Family Foundation N/AHHMI (HHMI) N/AHHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) K99DK120897HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK070855NIAID NIH HHS T32 AI005284NIDA NIH HHS R34 DA059509NIDDK NIH HHS K99 DK120897NIDDK NIH HHS R01 DK070855UNCF/Merck N/AWelch Foundation (The Welch Foundation) I-1874
6 · The paper itself

Abstract

Autophagy is a key innate immune defense mechanism in intestinal epithelial cells. Bacterial invasion of epithelial cells activates antibacterial autophagy through a process that requires the innate immune adaptor protein MYD88, yet how MYD88 signaling connects to the autophagy machinery is unknown. Here, we show that the mouse intestinal pathogen

Indexed as

AutophagyBeclin-1EnterocytesIntestinal MucosaMyeloid Differentiation Factor 88Proto-Oncogene Proteins c-bcl-2Salmonella typhimuriumAnimalsMiceMice, Inbred C57BLPhosphorylationSalmonella InfectionsSignal TransductionBcl2 protein, mouseBeclin-1Becn1 protein, mouseMyd88 protein, mouseMyeloid Differentiation Factor 88Proto-Oncogene Proteins c-bcl-2autophagyenterocyteinnate immunityintestinal epitheliumpathogenic bacteria

Identifiers

PMID39602254
PMCPMC11626146

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.