Evidence map›Paper›PMID 39602000›Full record

ArticleAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry2025

Line-dropped gelatin multi-element calibration standards in LA-ICP-MS: a statistically verifying comparison with cryosectioned homogenized lung and liver as matrix-matched calibration standards and as corresponding reference materials.

Sven Thoröe-Boveleth, Ruth Becker, Jens Bertram, Thomas Schettgen, Manfred Möller, Danny Jonigk, Thomas Kraus, Ralf Weiskirchen

Abstract readComparative Study
In one paragraph

Article in Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sven Thoröe-BovelethInstitute for Occupational, Social and Environmental Medicine (IASU), Medical Faculty, RWTH University Hospital Aachen, Pauwelsstraße 30, 52074, Aachen, Germany. sven.thoroe@rwth-aachen.de.ORCID http://orcid.org/0009-0008-8258-7971
Ruth BeckerInstitute for Occupational, Social and Environmental Medicine (IASU), Medical Faculty, RWTH University Hospital Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.
Jens BertramInstitute for Occupational, Social and Environmental Medicine (IASU), Medical Faculty, RWTH University Hospital Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.
Thomas SchettgenInstitute for Occupational, Social and Environmental Medicine (IASU), Medical Faculty, RWTH University Hospital Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.ORCID http://orcid.org/0000-0003-1256-1713
Manfred MöllerInstitute for Occupational, Social and Environmental Medicine (IASU), Medical Faculty, RWTH University Hospital Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.
Danny JonigkInstitute of Pathology, Medical Faculty, RWTH University Hospital Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.
Thomas KrausInstitute for Occupational, Social and Environmental Medicine (IASU), Medical Faculty, RWTH University Hospital Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.ORCID http://orcid.org/0000-0001-9747-3776
Ralf WeiskirchenInstitute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), Medical Faculty, RWTH University Hospital Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.ORCID http://orcid.org/0000-0003-3888-0931

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calibrations in LA-ICP-MS are typically very time-consuming and complex, as they need to be matched to the samples being measured and sectioned on a microtome. Alternatively, gelatin can be in droplet form or as a section, which is a more recent development. In this study, we report on investigations where hot multi-element gelatin solutions are placed in a linear fashion on microscopic slides to conduct comparative statistical observations between doped tissue homogenates from the liver and lung. The tissue homogenates served as both samples (complete ablation) and calibration standards (partial ablation) for verification purposes. We explored the effects of different laser fluences (0.50-1.50 J/cm

Indexed as

GelatinLiverLungMass SpectrometryAnimalsCalibrationReference StandardsGelatinCalibrationGelatinLA-ICP-MSTissue homogenatesVBA

Identifiers

PMID39602000
PMCPMC11832574

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.