Evidence map›Paper›PMID 39601969›Full record

SynthesisInternational journal of clinical oncology2025

Is it feasible to prolong the flushing interval for totally implantable venous access devices (TIVADs)? A systematic review and meta-analysis.

Lei Liu, Junli Liang, Zhanlun Liu, Yinghui Jin, Cuicui Ma, Xiaoyan Zhao, Mingyi Qin, Jinwei Wei, Xinsheng Li, Yanli Xie and 3 more

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in International journal of clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lei LiuThe Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Junli LiangThe Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Zhanlun LiuHebei Province Hospital of Traditional Chinese Medicine, Shijiazhuang, 050011, Hebei, China. 734490149@qq.com.
Yinghui JinCenter for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Cuicui MaThe Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Xiaoyan ZhaoThe Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Mingyi QinThe Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Jinwei WeiThe Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Xinsheng LiThe Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Yanli XieThe Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Fengxia LiuThe Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Laiyou LiThe Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Jianxin WangThe Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China. 911981500@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo ascertain the effects of prolonging flushing intervals (FIs) for Totally Implantable Venous Access Devices (TIVADs) on catheter-related complications in the off-treatment period.

methodsA preliminary search of PubMed, EMBASE, Cochrane, Web of Science, Web of Science, Scopus, CNKI, and SinoMed was conducted from inception to 6th June 2023, using the keywords "vascular access devices", "interval", "occlusion", and "complication". Two independent reviewers performed studies screening, quality assessment, and data extraction. The methodological quality of included articles was assessed using the Newcastle-Ottawa Scale (NOS) and Risk of Bias (ROB) tools. Meta-analysis and trial sequential analysis (TSA) was performed to calculate the risk ratios and 95% confidence interval (CI).

resultsEleven studies with 4,924 participants were included. Extending FIs to two or three months increased the risk of catheter occlusion compared to one-month intervals [RR = 1.50 (1.18-1.92), P = 0.001], but this finding was not confirmed by sensitivity analysis and TSA. Extending FIs to three months showed no significant effect on overall complications rates [RR = 1.21 (0.99-1.48), P = 0.49], consistent with sensitivity analysis and TSA results. For other catheter-related complications, the results showed extending the FIs to three months was feasible, but with weak measurements due to insufficient data.

conclusionData from the current included studies tended to support the feasibility of extending the flushing interval to every three months, with no expected increase in catheter occlusion or overall catheter complications. However, due to the inherent limitations of the included study, the findings of the current study should be interpreted with caution.

Indexed as

Vascular Access DevicesCatheterization, Central VenousCatheters, IndwellingCentral Venous CathetersFlushingHumansTime FactorsCatheter occlusionEpisode of careSystematic reviewTherapeutic irrigationVascular access devices

Identifiers

PMID39601969

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.