Evidence map›Paper›PMID 39601920›Full record

ArticleEuropean journal of pediatrics2024

Is Helicobacter pylori infection a risk factor for non-alcoholic fatty liver disease in children?

Sana Barakat, Mohamed Abdel-Fadeel, Ola Sharaki, Mohamed El Shafei, Basant Elbanna, Aml Mahfouz

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In one paragraph

Article in European journal of pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sana BarakatPaediatric Department, Faculty of Medicine, Alexandria University, Champollion Street El-Khartoum Square, Azarita Medical Campus 21311, Alexandria, Egypt.
Mohamed Abdel-FadeelPaediatric Department, Faculty of Medicine, Alexandria University, Champollion Street El-Khartoum Square, Azarita Medical Campus 21311, Alexandria, Egypt.
Ola SharakiClinical and Chemical Pathology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Mohamed El ShafeiDepartment of Diagnostic and Interventional Radiology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Basant ElbannaPaediatric Department, Faculty of Medicine, Alexandria University, Champollion Street El-Khartoum Square, Azarita Medical Campus 21311, Alexandria, Egypt. b_abdelazim14@alexmed.edu.eg.ORCID http://orcid.org/0009-0009-8493-9309
Aml MahfouzPaediatric Department, Faculty of Medicine, Alexandria University, Champollion Street El-Khartoum Square, Azarita Medical Campus 21311, Alexandria, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Helicobacter pylori infection has been investigated as a potential risk factor for non-alcoholic fatty liver disease (NAFLD). Some studies suggest a possible link between the two conditions. The purpose of this study is to study the relationship between H. pylori infection and NAFLD in pediatrics and its relation to NAFLD grades. A case-control study to identify predictors of NAFLD and a comparative cross-sectional approach to determine factors affecting NAFLD grades were adopted. One hundred NAFLD children (ultrasound-based) and a control group of 100 non-NAFLD children were recruited. Both groups were evaluated by detecting H. pylori stool antigen. Immunoglobulin G antibodies to Cag A (cytotoxin-associated gene A), Vac A (vacuolating cytotoxin A), Gro EL (chaperonin Gro EL), HCPC (Helicobacter cysteine-rich protein C), and Ure A (Urease subunit A) were assessed in the serum of those with positive stool antigen. H. pylori infection was significantly higher in NAFLD children compared to the control group (64% versus 25%, p-value < .001). (NAFLD children showed higher Cag A and Vac A positivity (34, 10%) versus (2%, 0%) in the control group, respectively, p-value < .001). The regression model showed that H. pylori positivity (OR (odds ratio) = 5.021, 95% CI (confidence interval): 1.105-22.815), homeostatic model assessment of insulin resistance (Homa IR) (OR = 18.840, 95% CI: 3.998-88.789), waist percentile (OR = 1.184, 95% CI: 1.044-1.344), and triglycerides (OR = 1.029, 95% CI: 1.012-1.047) were predictors for NAFLD. Cag A positivity (OR = 2.740, 95% CI: 1.013-7.411) was associated with higher NAFLD grade (grade 2 fatty liver).

conclusionsH. pylori infection could increase the risk of NAFLD in children. Triglycerides, waist circumference, and Homa IR are significant independent predictors of NAFLD. WHAT IS KNOWN: • NAFLD has become one of the most common liver diseases among children because of the increased prevalence of pediatric obesity. • Dyslipidemia and insulin resistance play a central role in NAFLD pathogenesis. • NAFLD could be explained by the multiple-hit hypothesis. The gut microbiota is an important factor in this hypothesis (gut liver axis). WHAT IS NEW: • Helicobacter pylori infection could increase the risk of NAFLD in children. • H. pylori Cytotoxin-associated gene A (Cag A) positivity is associated with higher NAFLD grade.

Indexed as

Helicobacter InfectionsHelicobacter pyloriNon-alcoholic Fatty Liver DiseaseAdolescentCase-Control StudiesChildCross-Sectional StudiesFecesFemaleHumansMaleRisk FactorsCytotoxin-associated gene AHelicobacter pyloriNon-alcoholic fatty liver diseaseVacuolating cytotoxin A

Identifiers

PMID39601920
PMCPMC11602778

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.