Evidence map›Paper›PMID 39601912›Full record

ArticleNeurochemical research2024

Doxophylline, a Non-Selective Phosphodiesterase Inhibitor, Protects Against Chronic Fatigue-Induced Neurobehavioral, Biochemical, and Mitochondrial Alterations.

Anushka Vashishth, Garima Sharma, Ankan Sarkar, Monika Kadian, Manish Jain, Anil Kumar

Abstract read
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In one paragraph

Article in Neurochemical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anushka VashishthUniversity Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India.
Garima SharmaUniversity Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India.
Ankan SarkarUniversity Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India.
Monika KadianUniversity Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India.
Manish JainUniversity Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India. jainm@pu.ac.in.
Anil KumarUniversity Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India. kumaruips@yahoo.com.

Funding

Department of Biotechnology, Ministry of Science and Technology, India BT/RLF/Re-entry/28/2019Department of Science and Technology, Government of India SUR/2022/002069
6 · The paper itself

Abstract

Chronic fatigue stress (CFS) is a multisystem disorder which exhibits multiple signs of neurological complications like brain fog, cognitive deficits and oxidative stress with no specific treatment. Doxophylline, a non-selective phosphodiesterase inhibitor (PDEI), has anti-inflammatory properties with enhanced blood-brain barrier penetration and tissue specificity. We have evaluated the neuroprotective potential of doxophylline in a murine model of forced swim test (FST) induced CFS and in H

Indexed as

Fatigue Syndrome, ChronicMitochondriaOxidative StressPhosphodiesterase InhibitorsAnimalsBehavior, AnimalBrainHydrogen PeroxideMaleMiceNeuroprotective AgentsPC12 CellsRatsReactive Oxygen SpeciesSwimmingTheophyllineHydrogen PeroxideNeuroprotective AgentsPhosphodiesterase InhibitorsReactive Oxygen SpeciesTheophyllineChronic fatigue stressDoxophyllineNeurological complicationsOxidative stressROS

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.