ArticleArchives of virology2024
Calcitriol reduces Newcastle disease virus replication by modulating galectin 3 and pro-inflammatory cytokines.
Article in Archives of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Study of Calcitriol Interaction with the Vitamin D Receptor Using DFT and TD-DFT Calculations.The journal of physical chemistry. B · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Calcitriol, or vitamin D (Vit D), is known for promoting strong bones and its ability to modulate inflammation and support the immune system. It has also been reported to be a potent antiviral agent, but the underlying mechanisms behind the mode of action are still unclear. Newcastle disease virus (NDV) belongs to the family Paramyxoviridae and causes infectious diseases in numerous avian species. In the present study, we explored the use of calcitriol as an antiviral agent against NDV infection. Post-treatment with calcitriol (the most active form of Vit D) was found to inhibit NDV replication in chicken embryo fibroblast cells (DF-1) in a time-of-addition- and concentration-dependent manner. The titer of NDV in allantoic fluid exhibited a substantial decrease after administration of cholecalciferol (the less active form of Vit D) to a 9-day-old chicken embryo. In addition, the results demonstrated a significant modulation of galectin 3 gene expression after NDV infection. Cytokine profiling of DF-1 cells treated with calcitriol and aloe-emodin, a known modulator of galectin 3, revealed significant upregulation of pro-inflammatory cytokines. The study indicates that calcitriol modulates host proteins, affecting NDV replication. These findings suggest that calcitriol or Vit D has the potential to be developed as an alternative antiviral drug against NDV, warranting further investigation.
Indexed as
Identifiers
39601906What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.