Evidence map›Paper›PMID 39601776›Full record

ArticleACS synthetic biology2024

Bacteria Engineered to Produce Serotonin Modulate Host Intestinal Physiology.

Chrystal F Mavros, Mareike Bongers, Frederik B F Neergaard, Frank Cusimano, Yiwei Sun, Andrew Kaufman, Miles Richardson, Susanne Kammler, Mette Kristensen, Morten O A Sommer and 1 more

Abstract read
In one paragraph

Article in ACS synthetic biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chrystal F MavrosDepartment of Systems Biology, Columbia University Irving Medical Center, New York, New York 10032, United States.ORCID 0000-0003-3914-7512
Mareike BongersNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby DK 2800, Denmark.
Frederik B F NeergaardNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby DK 2800, Denmark.
Frank CusimanoDepartment of Systems Biology, Columbia University Irving Medical Center, New York, New York 10032, United States.
Yiwei SunDepartment of Systems Biology, Columbia University Irving Medical Center, New York, New York 10032, United States.
Andrew KaufmanDepartment of Systems Biology, Columbia University Irving Medical Center, New York, New York 10032, United States.
Miles RichardsonDepartment of Systems Biology, Columbia University Irving Medical Center, New York, New York 10032, United States.
Susanne KammlerNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby DK 2800, Denmark.
Mette KristensenNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby DK 2800, Denmark.
Morten O A SommerNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby DK 2800, Denmark.ORCID 0000-0003-4005-5674
Harris H WangDepartment of Systems Biology, Columbia University Irving Medical Center, New York, New York 10032, United States.ORCID 0000-0003-2164-4318

Funding

Center for Genomic Editing and Recording: Development and Application of Next-Generation Genome and Epigenome Editing Methods to Advance the Study and Treatment of Human DiseaseRM1HG009490 · NHGRI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI Brittany S. Adamson, Martin Joseph Ankrah Aryee · 2017 to 2026
$22.7M
Micron-scale Spatial Metagenomic Mapping of Microbial Biogeography in the Gastrointestinal TractR01AI132403 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Harris H Wang · 2017 to 2026
$6.0M
Ecological dynamics and metabolic interactions in thegut microbiome across space and timeR01DK118044 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI VITKUP, DENNIS, WANG, HARRIS H · 2018 to 2022
$3.4M
A high-performance and versatile technology for precision microbiome engineeringR01EB031935 · NIBIB · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Samuel Henry Sternberg, Harris H Wang · 2021 to 2026
$3.3M
Discovery of immunomodulatory gut microbes with MAGICR21AI146817 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI IVANOV, IVAYLO IVANOV · 2019 to 2020
$437k
NHGRI NIH HHS RM1 HG009490NIAID NIH HHS R01 AI132403NIAID NIH HHS R21 AI146817NIBIB NIH HHS R01 EB031935NIDDK NIH HHS R01 DK118044Wellcome Trust PATH1016691
6 · The paper itself

Abstract

Bacteria in the gastrointestinal tract play a crucial role in intestinal motility, homeostasis, and dysfunction. Unraveling the mechanisms by which microbes impact the host poses many challenges due to the extensive array of metabolites produced or metabolized by bacteria in the gut. Here, we describe the engineering of a gut commensal bacterium,

Indexed as

Escherichia coliGastrointestinal MicrobiomeSerotoninAnimalsHumansIntestinesMetabolic EngineeringMiceMice, Inbred C57BLSerotonin5-HTE. coli Nissle 1917engineered probioticgut-brainmicrobiome engineeringserotonin

Identifiers

PMID39601776
PMCPMC12016422

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.