Evidence map›Paper›PMID 39601762›Full record

ArticleAmerican journal of respiratory and critical care medicine2025

Type 1 Immune Responses Related to Viral Infection Influence Corticosteroid Response in Asthma.

John V Fahy, Nathan D Jackson, Satria P Sajuthi, Elmar Pruesse, Camille M Moore, Jamie L Everman, Cydney Rios, Monica Tang, Marc Gauthier, Sally E Wenzel and 17 more

Abstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Viral and Host-Related Factors in the Nasal Inflammatory Response to Critical Bronchiolitis in Infants and Children.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2026
    Article
  5. Airway epithelial heterogeneity and mucus plugging in asthmatic bronchioles.American journal of respiratory and critical care medicine · 2026
    Article
  6. Review
  7. Article
  8. Immunotherapy for asthma.Cellular & molecular immunology · 2025
    Review
  9. Article
  10. Article
  11. Review
  12. The immunology of asthma.Nature immunology · 2025
    Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. In Asthma, Change Is the Only Constant.American journal of respiratory and critical care medicine · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors.

John V FahyDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of California San Francisco, San Francisco, California.
Nathan D JacksonCenter for Genes, Environment, and Health and.
Satria P SajuthiCenter for Genes, Environment, and Health and.
Elmar PruesseCenter for Genes, Environment, and Health and.
Camille M MooreCenter for Genes, Environment, and Health and.
Jamie L EvermanCenter for Genes, Environment, and Health and.
Cydney RiosCenter for Genes, Environment, and Health and.
Monica TangDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of California San Francisco, San Francisco, California.ORCID 0000-0001-8847-5817
Marc GauthierDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.ORCID 0000-0001-5037-2804
Sally E WenzelDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.ORCID 0000-0002-4242-0164
Eugene R BleeckerDivision of Genetics, Genomics, and Precision Medicine, Department of Medicine, University of Arizona, Tucson, Arizona.
Mario CastroDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Kansas School of Medicine, The University of Kansas Medical Center, Kansas City, Kansas.ORCID 0000-0001-6328-8994
Suzy A ComhairLerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Serpil C ErzurumLerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Annette T HastieDepartment of Internal Medicine, School of Medicine, Wake Forest University, Winston-Salem, North Carolina.ORCID 0000-0001-6607-7797
Wendy MooreDepartment of Internal Medicine, School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
Elliot IsraelDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Bruce D LevyDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0001-9515-5731
Loren DenlingerDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Nizar N JarjourDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Mats W JohanssonDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
David T MaugerDivision of Statistics and Bioinformatics, Department of Public Health Sciences, Pennsylvania State University, Hershey, Pennsylvania.
Brenda R PhillipsDivision of Statistics and Bioinformatics, Department of Public Health Sciences, Pennsylvania State University, Hershey, Pennsylvania.
Kaharu SuminoDivision of Pulmonary Critical Care Medicine, Washington University, St. Louis, Missouri; and.
Prescott G WoodruffDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of California San Francisco, San Francisco, California.
Michael C PetersDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of California San Francisco, San Francisco, California.
Max A SeiboldCenter for Genes, Environment, and Health and.

Funding

Understanding Asthma EndotypesU19AI077439 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2008 to 2026
$41.1M
Role of miRNAs in Th2-Driven inflammation in AsthmaP01HL107202 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOCKSLEY, RICHARD M · 2012 to 2023
$23.3M
Rapid saliva antigen test for SARS-CoV-2 detectionU01HL146002 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ARONICA, MARK A, CASTRO, MARIO · 2019 to 2023
$17.3M
Protein carbohydrate interactions in the pathophysiology of asthma exacerbationsR01HL080414 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI John V Fahy · 2005 to 2026
$9.2M
Transcriptomic and Genetic Endotyping of Exacerbation-Prone AsthmaticsP01HL132821 · NHLBI · NATIONAL JEWISH HEALTH · PI SEIBOLD, MAX A · 2017 to 2021
$9.0M
Clinical Coordinating Center for the Severe Asthma Research Program (SARP)U10HL109086 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI MAUGER, DAVID T. · 2011 to 2017
$8.1M
AMSA: ALXR/FBR Mediated Signaling in Severe AsthmaU10HL109172 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ISRAEL, ELLIOT, LEVY, BRUCE D · 2011 to 2016
$4.2M
Airway redox biochemistry as a deteriminant of asthma phenotype during adolescen*U10HL109250 · NHLBI · UNIVERSITY OF VIRGINIA · PI ERZURUM, SERPIL C., GASTON, BENJAMIN · 2011 to 2016
$4.2M
Transcriptomic and Pharmacogenetic Asthma Endotypes in Minority ChildrenR01HL135156 · NHLBI · NATIONAL JEWISH HEALTH · PI SEIBOLD, MAX A, ZIV, ELAD · 2017 to 2021
$4.1M
Clinical and Molecular Phenotypes of Severe AsthmaU10HL109146 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FAHY, JOHN V · 2011 to 2016
$4.0M
Implications and Stability of Clinical and Molecular Phenotypes of Severe AsthmaU10HL109152 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WENZEL, SALLY E · 2011 to 2016
$3.9M
Stability of Severe Asthma Phenotypes: Impact of ExacerbationsU10HL109168 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI JARJOUR, NIZAR N · 2011 to 2016
$3.9M
NHLBI NIH HHS K08 HL164887NHLBI NIH HHS P01 HL107202NHLBI NIH HHS P01 HL132821NHLBI NIH HHS R01 HL080414NHLBI NIH HHS R01 HL135156NHLBI NIH HHS R01 HL164787NHLBI NIH HHS U01 HL146002NHLBI NIH HHS U10 HL109086NHLBI NIH HHS U10 HL109146NHLBI NIH HHS U10 HL109152NHLBI NIH HHS U10 HL109164NHLBI NIH HHS U10 HL109168NHLBI NIH HHS U10 HL109172NHLBI NIH HHS U10 HL109250NHLBI NIH HHS U10 HL109257NIAID NIH HHS U19 AI077439NIH HHS P01 HL107202NIH HHS P01 HL132821NIH HHS R01 HL080414NIH HHS R01 HL135156NIH HHS U01 HL146002NIH HHS U10 HL109086NIH HHS U10 HL109146NIH HHS U10 HL109152NIH HHS U10 HL109164NIH HHS U10 HL109168NIH HHS U10 HL109172NIH HHS U10 HL109250NIH HHS U10 HL109257
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adrenal Cortex HormonesAsthmaVirus DiseasesAdultFemaleHumansMaleMiddle AgedSputumTreatment OutcomeAdrenal Cortex Hormonessputumtranscriptomicstype 1 asthmatype 2 asthmaviral metagenomics

Identifiers

PMID39601762
PMCPMC11812531

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.